A potent and selective bradykinin B2 antagonist. HOE-140 is a useful tool for discrimination of the physiological roles of bradykinin B2 versus B1 receptors. Displays a protective effect in myocardial reperfusion injury.
Product Details
| Alternative Name: | Icatibant |
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| Sequence: | D-Arg-Arg-Pro-Hyp-Gly-Thi-Ser-Tic-Oic-Arg |
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| Formula: | C59H89N19O13S |
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| MW: | 1304.5 |
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| CAS: | 130308-48-4 |
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| Purity: | ≥95% (HPLC) |
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| Identity: | Determined by MS. |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Characterization of the Kallikrein-Kinin System Post Chemical Neuronal Injury: An In Vitro Biochemical and Neuroproteomics Assessment: A. Nokkari, et al.; PLoS One
10, e0128601 (2015),
Application(s): Cell Culture,
Abstract;
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BK2 but not BK1 receptors mediating contractile response in human umbilical arteries: role of thromboxane A2: A. Tiritilli, et al.; Methods Find. Exp. Clin. Pharmacol.
26, 247 (2004),
Abstract;
Bradykinin regulates cyclooxygenase-2 in rat renal thick ascending limb cells: J. A. Rodriguez, et al.; Hypertension
44, 230 (2004),
Abstract;
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Correlation between brain bradykinin receptor binding sites and cardiovascular function in young and adult spontaneously hypertensive rats: F. Cloutier, et al.; Br. J. Pharmacol.
142, 285 (2004),
Abstract;
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Protective effect of bradykinin antagonist Hoe-140 during in vivo myocardial ischemic-reperfusion injury in the cat: R. Kumari, et al.; Regul. Pept.
115, 211 (2003),
Abstract;
