Antihistamine that possesses cognition-enhancing properties. Blocks mitochondrial permeability transition pore opening induced by MPP+ and β-amyloid. Has been shown to interact with a number of molecular targets including acetylcholinesterases, NMDA receptors and L-type calcium channels as well as acting as an antagonist at 5-HT6 receptors. Dimebon significantly improved the clinical course of patients with mild-to-moderate Alzheimer’s disease in a randomized, double-blind, placebo-controlled study.
Product Details
| Alternative Name: | 2,3,4,5-Tetrahydro-2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)ethyl)-1H-pyrido(4,3-b)indole . 2HCl |
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| Formula: | C21H25N3 . 2HCl |
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| MW: | 319.4 . 73.0 |
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| CAS: | 97657-92-6 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white/pale purple solid. |
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| Solubility: | Soluble in water (>25mg/ml) or DMSO (10mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities: H. Schaffhauser, et al.; Biochem. Pharmacol.
78, 1035 (2009),
Abstract;
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer’s disease: a randomised, double-blind, placebo-controlled study: R.S. Doody, et al.; Lancet
372, 207 (2008),
Abstract;
Mitochondria as a target for neurotoxins and neuroprotective agents: S.O. Bachurin, et al.; Ann. N.Y. Acad. Sci.
993, 334 (2003),
Abstract;
Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer: S. Bachurin, et al.; Ann. N.Y. Acad. Sci.
939, 425 (2001),
Abstract;
