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Dimebon . 2HCl

Antihistamine with cognition-enhancing properties
BML-NH112-0050 50 mg 765.00 USD
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Antihistamine that possesses cognition-enhancing properties. Blocks mitochondrial permeability transition pore opening induced by MPP+ and β-amyloid. Has been shown to interact with a number of molecular targets including acetylcholinesterases, NMDA receptors and L-type calcium channels as well as acting as an antagonist at 5-HT6 receptors. Dimebon significantly improved the clinical course of patients with mild-to-moderate Alzheimer’s disease in a randomized, double-blind, placebo-controlled study.

Product Details

Alternative Name:2,3,4,5-Tetrahydro-2,8-dimethyl-5-(2-(6-methyl-3-pyridyl)ethyl)-1H-pyrido(4,3-b)indole . 2HCl
Formula:C21H25N3 . 2HCl
MW:319.4 . 73.0
Purity:≥98% (TLC)
Appearance:Off-white/pale purple solid.
Solubility:Soluble in water (>25mg/ml) or DMSO (10mg/ml).
Long Term Storage:Ambient
Use/Stability:Store solutions at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Dimebolin is a 5-HT6 antagonist with acute cognition enhancing activities: H. Schaffhauser, et al.; Biochem. Pharmacol. 78, 1035 (2009), Abstract;
Effect of dimebon on cognition, activities of daily living, behaviour, and global function in patients with mild-to-moderate Alzheimer’s disease: a randomised, double-blind, placebo-controlled study: R.S. Doody, et al.; Lancet 372, 207 (2008), Abstract;
Mitochondria as a target for neurotoxins and neuroprotective agents: S.O. Bachurin, et al.; Ann. N.Y. Acad. Sci. 993, 334 (2003), Abstract;
Antihistamine agent Dimebon as a novel neuroprotector and a cognition enhancer: S. Bachurin, et al.; Ann. N.Y. Acad. Sci. 939, 425 (2001), Abstract;

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