Replaces Prod. #: ALX-550-130
Potent and selective histamine H3 agonist. Crosses the blood-brain barrier and inhibits histamine synthesis and release at nanomolar concentrations.
Product Details
| Formula: | C6H11N3 . 2HBr |
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| MW: | 287.0 |
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| CAS: | 868698-49-1 |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in water (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Handling: | Very hygroscopic. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Characterization of histamine H3-receptors in guinea-pig ileum with H3-selective ligands: R.W. Hew, et al.; Br. J. Pharmacol.
101, 621 (1990),
Abstract;
Distribution, properties, and functional characteristics of three classes of histamine receptor: S.J. Hill; Pharmacol. Rev.
42, 45 (1990),
Abstract;
Plenary lecture. A third histamine receptor subtype: characterisation, localisation and functions of the H3-receptor: J.C. Schwartz, et al.; Agents Actions
30, 13 (1990),
Abstract;
Effects of the histamine H3-agonist (R)-alpha-methylhistamine and the antagonist thioperamide on histamine metabolism in the mouse and rat brain: R. Oishi, et al.; J. Neurochem.
52, 1388 (1989),
Abstract;
Highly potent and selective ligands for histamine H3-receptors: J.M. Arrang, et al.; Nature
327, 117 (1987),
Abstract;
