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Neuron specific enolase monoclonal antibody (47)

BML-NA1501-0100 100 µl 116.00 USD
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Product Specification

Alternative Name:NSE, γ, γ'-enolase, Enolase 2, ENO2
Immunogen:Neuron-specific enolase extracted from cow brain.
UniProt ID:P09104 (human)
Species reactivity:Mammalian
Specificity:Recognizes NSE in a wide range of mammalian species.
Applications:ELISA, IHC, WB
Application Notes:Detects a band of ~76kDa by Western blot.
Purity Detail:Partially purified.
Formulation:Liquid. In PBS containing 0.01M sodium azide.
Shipping:Shipped on Blue Ice
Long Term Storage:-20°C
Scientific Background:The glycolytic enzyme enolase (2-phospho-D-glycerate hydrolase) is composed of two subunits and exists in three molecular forms in human brain: non-neuronal enolase (NNE; α,α’-enolase), neuron-specific enolase (NSE; γ,γ’-enolase, also known as 14-3-2 protein and NSP) and the short-lived heterodimer α,γ’-enolase. The neuron-specific form is a highly acidic homodimeric protein of 78kDa which has been found in central and peripheral nervous elements and also in many neuroendocrine cells and derivative tumours. NSE is regarded as the best described serum marker for small cell lung cancer (SCLC). In addition, the measurement of NSE levels in both serum and cerebrospinal fluid following cerebral ischaemia and traumatic head injury provides a reliable laboratory indicator of the degree of brain cell damage and may allow early prediction of prognostic outcome.
Regulatory Status:RUO - Research Use Only

Product Literature References

MiR-155 deletion reduces ischemia-induced paralysis in an aortic aneurysm repair mouse model: Utility of immunohistochemistry and histopathology in understanding etiology of spinal cord paralysis: H. Awad, et al.; Ann. Diagn. Pathol. 36, 12 (2018), Abstract; Full Text

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