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Lorcainide . HCl

Na+ channel blocker
BML-NA143-0010 10 mg 105.00 USD
BML-NA143-0050 50 mg 407.00 USD
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Possesses both local anesthetic and antiarrhythmic properties (class 1C agent). Elevates the ventricular fibrillation threshold and protects against ouabain-induced arrhythmias in animal models. Its mechamism of action is primarly inhibition of sodium channels in a voltage- and frequency-dependent fashion. Also inhibits the microsomal Na+,K+-ATPase in a concentration-dependent manner (IC50=33.5µM) . Reduces neuronal death in cellular models of hypoxic injury when combined with a glutamate receptor antagonist and blocks aconitine-induced mortality in a rat model (ED50=30mg/kg).

Product Details

Alternative Name:N-(4-Chlorophenyl)-N-[1-(1-isopropyl)-4-piperidinyl]phenylacetamide . HCl
Formula:C22H27ClN2O . HCl
MW:370.9 . 36.5
Purity:≥98% (TLC)
Appearance:White solid.
Solubility:Soluble in water (>30mg/ml), DMSO (>25mg/ml) or 100% ethanol (>25mg/ml).
Shipping:Ambient Temperature
Long Term Storage:Ambient
Use/Stability:Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
BML-NA143 structure
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BML-NA143 structure

Product Literature References

Sodium channel blockers reduce oxygen-glucose deprivation-induced cortical neuronal injury when combined with glutamate receptor antagonists: J.J. Lynch, 3rd, et al.; J. Pharmacol. Exp. Ther. 273, 554 (1995), Abstract;
Influence of lorcainide on microsomal Na+, K(+)-ATPase in guinea-pig isolated heart preparations: A.A. Almotrefi & N. Dzimiri; Br. J. Pharmacol. 102, 530 (1991), Abstract;
Antiarrhythmic drugs and the cardiac sodium channel: current models: R.S. Sheldon, et al.; Clin. Chem. 35, 748 (1989), Abstract;
Inhibition of aconitine-induced mortality in the conscious rat: a screening test for antiarrhythmic drugs: B. Gutierrez, et al.; Methods Find. Exp. Clin. Pharmacol. 9, 307 (1987), Abstract;

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