Batrachotoxin is a potent neurotoxin and cardiotoxin found in the skin of various poisonous frogs. BTX binds specifically to voltage-gated Na+ channels causing steady state activation, preventing all forms of inactivation, slowing deactivation and altering ion selectivity.
Use extreme caution! May cause death.
Product Details
| Alternative Name: | BTX |
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| Formula: | C31H42N2O6 |
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| MW: | 538.7 |
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| CAS: | 23509-16-2 |
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| Purity: | ≥90% (HPLC, TLC, Toxicity) |
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| Appearance: | Thin film. |
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| Solubility: | Soluble in DMSO, methanol or 100% ethanol. |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
How batrachotoxin modifies the sodium channel permeation pathway: computer modeling and site-directed mutagenesis: S. Y. Wang, et al.; Mol. Pharmacol.
69, 788 (2006),
Abstract;
Full Text
Binding of the anticonvulsant drug lamotrigine and the neurotoxin batrachotoxin to voltage-gated sodium channels induces conformational changes associated with block and steady-state activation: N. B. Cronin, et al.; J. Biol. Chem.
278, 10675 (2003),
Abstract;
Full Text
