PD-85839 is a potent and selective sodium channel blocker. It binds specifically to a local anesthetic receptor site on the Na+ channel alpha subunit that is allosterically linked to neurotoxin receptor site 21. PD-85639 is a novel and useful molecular probe of this important drug receptor site.
Product Details
| Formula: | C24H32N2O |
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| MW: | 364.5 |
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| CAS: | 150034-24-5 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (5mg/ml) or ethanol (4mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Sodium and potassium channel modulators: their role in neuroprotection: T. P. Obrenovitch, et al.; Int. Rev. Neurobiol.
40, 109 (1997),
Abstract;
Inhibition of Na+ channels by the novel blocker PD85,639: D. S. Ragsdale, et al.; Mol. Pharmacol.
43, 949 (1993),
Abstract;
Specific binding of the novel Na+ channel blocker PD85,639 to the alpha subunit of rat brain Na+ channels: W. Thomsen, et al.; Mol Pharmacol.
43, 955 (1993),
Abstract;
