Kavain is one constituent of kava-kava, an herbal drug of the South Pacific islands, which displays anti-convulsive, anxiolytic, analgesic and muscle relaxing properties. Kavain inhibits voltage-dependent Na+ channels in rat CA1 hippocampal neurons. It displays protective effects in the MPTP mouse model of Parkinson's disease but potentiates NMDA toxicity in the developing hippocampus.
Product Details
| Alternative Name: | (±)-4-Methoxy-6-styryl-5,6-dihydro-α-pyrone |
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| Formula: | C14H14O3 |
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| MW: | 230.3 |
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| CAS: | 500-64-1 |
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| Purity: | ≥98% |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Post-insult exposure to (+/-) kavain potentiates N-methyl-D-aspartate toxicity in the developing hippocampus: P. J. Mulholland, et al.; Brain Res.
945, 106 (2002),
Abstract;
Neuroprotective effects of (+/-)-kavain in the MPTP mouse model of Parkinson's disease: N. Schmidt, et al.; Synapse
40, 47 (2001),
Abstract;
Kava extract ingredients, (+)-methysticin and (+/-)-kavain inhibit voltage-operated Na(+)-channels in rat CA1 hippocampal neurons: E. I. Magura, et al.; Neuroscience
81, 345 (1997),
Abstract;
