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Na+ channel activator
BML-NA125-0010 10 mg 171.00 USD
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Replaces Prod. #: ALX-550-307

A Na+ channel activator. Does not affect Na+-Ca2+ exchange. Veratridine acts at neurotoxin receptor site 2 and preferentially binds to activated Na+ channels causing persistent activation. It prevents inactivation and shifts activation to more negative potentials. Induces cell death in bovine chromaffin cells.

Product Details

Purity:≥98% (TLC)
Appearance:White to yellow solid.
Solubility:Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml).
Shipping:Ambient Temperature
Short Term Storage:-20°C
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Regulatory Status:RUO - Research Use Only
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Product Literature References

A high-capacity membrane potential FRET-based assay for NaV1.8 channels: C.J. Liu, et al.; Assay Drug Dev. Technol. 4, 37 (2006), Abstract;
Depolarization preconditioning produces cytoprotection against veratridine-induced chromaffin cell death: C. Orozco, et al.; Eur. J. Pharmacol. 553, 28 (2006), Abstract;
Effects of veratrine and veratridine on oxygen consumption and electrical membrane potential of isolated rat skeletal muscle and liver mitochondria: E.M. Silva Freitas et al.; Toxicon 47, 780 (2006), Abstract;
Excessive release of [3H] noradrenaline by veratridine and ischemia in spinal cord: Y. Sumiya et al.; Neurochem. Int. 39, 59 (2001), Abstract;
Alteration of veratridine neurotoxicity in sympathetic neurons during development in vitro: T. Koike & T. Ninomiya; Neuroreport 11, 151 (2000), Abstract;
Veratridine induces apoptotic death in bovine chromaffin cells through superoxide production: J. Jordan et al.; Br. J. Pharmacol. 130, 1496 (2000), Abstract;
Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine: R. Maroto et al.; Eur. J. Pharmacol. 270, 331 (1994), Abstract;
Veratridine triggers exocytosis in Paramecium cells by activating somatic Ca channels: H. Plattner et al.; J. Membr. Biol. 142, 229 (1994), Abstract;
Rapid and slow gating of veratridine-modified sodium channels in frog myelinated nerve: T.A. Rando; J. Gen. Physiol. 93, 43 (1989), Abstract;
Kinetics of veratridine action on Na channels of skeletal muscle: J.B. Sutro; J. Gen. Physiol. 87, 1 (1986), Abstract;
Purification, solubility, and pKa of veratridine: L.C. McKinney et al.; Anal. Biochem. 153, 33 (1986), Abstract;
The interaction between the activator agents batrachotoxin and veratridine and the gating processes of neuronal sodium channels: T.A. Rando et al.; Mol. Pharmacol. 29, 467 (1986), Abstract;
Voltage-dependent gating of veratridine-modified Na channels: M.D. Leibowitz et al.; J. Gen. Physiol. 87, 25 (1986), Abstract;
Comparative pharmacology of voltage-dependent sodium channels: W.B. Stallcup; Brain Res. 135, 37 (1977), Abstract;

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