Replaces Prod. #: ALX-550-307
A Na+ channel activator. Does not affect Na+-Ca2+ exchange. Veratridine acts at neurotoxin receptor site 2 and preferentially binds to activated Na+ channels causing persistent activation. It prevents inactivation and shifts activation to more negative potentials. Induces cell death in bovine chromaffin cells.
Product Details
| Formula: | C36H51NO11 |
| |
| MW: | 673.8 |
| |
| CAS: | 71-62-5 |
| |
| Purity: | ≥98% (TLC) |
| |
| Appearance: | White to yellow solid. |
| |
| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
| |
| Shipping: | Ambient Temperature |
| |
| Short Term Storage: | -20°C |
| |
| Long Term Storage: | -20°C |
| |
| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
A high-capacity membrane potential FRET-based assay for NaV1.8 channels: C.J. Liu, et al.; Assay Drug Dev. Technol.
4, 37 (2006),
Abstract;
Depolarization preconditioning produces cytoprotection against veratridine-induced chromaffin cell death: C. Orozco, et al.; Eur. J. Pharmacol.
553, 28 (2006),
Abstract;
Effects of veratrine and veratridine on oxygen consumption and electrical membrane potential of isolated rat skeletal muscle and liver mitochondria: E.M. Silva Freitas et al.; Toxicon
47, 780 (2006),
Abstract;
Excessive release of [3H] noradrenaline by veratridine and ischemia in spinal cord: Y. Sumiya et al.; Neurochem. Int.
39, 59 (2001),
Abstract;
Alteration of veratridine neurotoxicity in sympathetic neurons during development in vitro: T. Koike & T. Ninomiya; Neuroreport
11, 151 (2000),
Abstract;
Veratridine induces apoptotic death in bovine chromaffin cells through superoxide production: J. Jordan et al.; Br. J. Pharmacol.
130, 1496 (2000),
Abstract;
Effects of Ca2+ channel antagonists on chromaffin cell death and cytosolic Ca2+ oscillations induced by veratridine: R. Maroto et al.; Eur. J. Pharmacol.
270, 331 (1994),
Abstract;
Veratridine triggers exocytosis in Paramecium cells by activating somatic Ca channels: H. Plattner et al.; J. Membr. Biol.
142, 229 (1994),
Abstract;
Rapid and slow gating of veratridine-modified sodium channels in frog myelinated nerve: T.A. Rando; J. Gen. Physiol.
93, 43 (1989),
Abstract;
Kinetics of veratridine action on Na channels of skeletal muscle: J.B. Sutro; J. Gen. Physiol.
87, 1 (1986),
Abstract;
Purification, solubility, and pKa of veratridine: L.C. McKinney et al.; Anal. Biochem.
153, 33 (1986),
Abstract;
The interaction between the activator agents batrachotoxin and veratridine and the gating processes of neuronal sodium channels: T.A. Rando et al.; Mol. Pharmacol.
29, 467 (1986),
Abstract;
Voltage-dependent gating of veratridine-modified Na channels: M.D. Leibowitz et al.; J. Gen. Physiol.
87, 25 (1986),
Abstract;
Comparative pharmacology of voltage-dependent sodium channels: W.B. Stallcup; Brain Res.
135, 37 (1977),
Abstract;
