Replaces Prod. #: ALX-630-002
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Tetrodotoxin is a non-peptide toxin isolated from ovaries and liver of Chinese puffer fish. Neurotoxin. Potent and reversible inhibitor of the voltage dependent Na+ channels in nerve membranes.
Product Details
| Alternative Name: | TTX, Fugu poison |
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| Formula: | C11H17N3O8 |
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| MW: | 319.3 |
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| CAS: | 4368-28-9 |
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| MI: | 14: 9246 |
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| RTECS: | IO1450000 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in dilute acetic acid (e.g. 1mg/ml in 10mM HOAc or 10mg/ml in 0.1M HOAc) or in citric acid/sodium citrate buffer, pH 4.8 (e.g. 1mg/ml in 20mM buffer). Do not use alkaline solution. |
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| Shipping: | Ambient Temperature |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Avoid strongly acidic or alkaline solutions. USE EXTREME CAUTION! MAY CAUSE DEATH. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action: K. Suzuki, et al.; Cell Rep.
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Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission: M.P. McCabe, et al.; Elife
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Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study: M. Ganguly, et al.; Neurophotonics
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Full Text
Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons: X. Sun, et al.; Life Sci.
194, 49 (2018),
Abstract;
Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors: T. Chernov-Rogan, et al.; PNAS
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Abstract;
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Upregulation of Voltage-Gated Calcium Channel Cav1.3 in Bovine Somatotropes Treated with Ghrelin: V.M. Salinas Zarate, et al.; J. Signal Transduct.
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Full Text
Tetrodotoxin poisoning: D.F. Hwang & T. Noguchi; Adv. Food Nutr. Res.
52, 141 (2007),
Abstract;
Recent advances in the study of mechanism of action of marine neurotoxins: T. Narahashi, et al.; Neurotoxicology
15, 545 (1994),
Abstract;
Functional properties of rat brain sodium channels expressed in a somatic cell line: T. Scheuer, et al.; Science
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Abstract;
Structure and function of voltage-sensitive ion channels: W.A. Catterall; Science
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Abstract;
Molecular properties of voltage-sensitive sodium channels: W.A. Catterall; Annu. Rev. Biochem.
55, 953 (1986),
Abstract;
Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes: W.A. Catterall; Annu. Rev. Pharmacol. Toxicol.
20, 15 (1980),
Abstract;
The constituents of the ovaries of globefish. VIII. Studies on tetrodotoxin: K. Tsuda & M. Kawamura; Pharm. Bull.
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