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Na+ channel blocker
BML-NA120-0001 1 mg Inquire for pricing
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Replaces Prod. #: ALX-630-002

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Tetrodotoxin is a non-peptide toxin isolated from ovaries and liver of Chinese puffer fish. Neurotoxin. Potent and reversible inhibitor of the voltage dependent Na+ channels in nerve membranes.

Product Details

Alternative Name:TTX, Fugu poison
MI:14: 9246
Purity:≥98% (HPLC)
Appearance:White to off-white solid.
Solubility:Soluble in dilute acetic acid (e.g. 1mg/ml in 10mM HOAc or 10mg/ml in 0.1M HOAc) or in citric acid/sodium citrate buffer, pH 4.8 (e.g. 1mg/ml in 20mM buffer). Do not use alkaline solution.
Shipping:Ambient Temperature
Short Term Storage:-20°C
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Avoid strongly acidic or alkaline solutions. USE EXTREME CAUTION! MAY CAUSE DEATH.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Nano-organization of spontaneous GABAergic transmission directs its autonomous function in neuronal signaling: N.J. Guzikowski & E.T. Kavalali; Cell Rep. 40, 111172 (2022), Abstract;
Presynaptic mechanisms underlying GABAB-receptor-mediated inhibition of spontaneous neurotransmitter release: B. Alten, et al.; Cell Rep. 38, 110255 (2022), Abstract;
A subthreshold synaptic mechanism regulating BDNF expression and resting synaptic strength: P.M. Horvath, et al.; Cell Rep. 36, 109467 (2021), Abstract;
Convergence of distinct signaling pathways on synaptic scaling to trigger rapid antidepressant action: K. Suzuki, et al.; Cell Rep. 37, 109918 (2021), Abstract;
Genetic inactivation of mTORC1 or mTORC2 in neurons reveals distinct functions in glutamatergic synaptic transmission: M.P. McCabe, et al.; Elife 9, e51440 (2020), Abstract;
Voltage-gated potassium channels are critical for infrared inhibition of action potentials: an experimental study: M. Ganguly, et al.; Neurophotonics 6, 040501 (2019), Abstract; Full Text
Calcimimetic R568 inhibits tetrodotoxin-sensitive colonic electrolyte secretion and reduces c-fos expression in myenteric neurons: X. Sun, et al.; Life Sci. 194, 49 (2018), Abstract;
Mechanism-specific assay design facilitates the discovery of Nav1.7-selective inhibitors: T. Chernov-Rogan, et al.; PNAS 115, E792 (2018), Abstract; Full Text
Upregulation of Voltage-Gated Calcium Channel Cav1.3 in Bovine Somatotropes Treated with Ghrelin: V.M. Salinas Zarate, et al.; J. Signal Transduct. 2013, 527253 (2013), Abstract; Full Text
Tetrodotoxin poisoning: D.F. Hwang & T. Noguchi; Adv. Food Nutr. Res. 52, 141 (2007), Abstract;
Recent advances in the study of mechanism of action of marine neurotoxins: T. Narahashi, et al.; Neurotoxicology 15, 545 (1994), Abstract;
Functional properties of rat brain sodium channels expressed in a somatic cell line: T. Scheuer, et al.; Science 247, 854 (1990), Abstract;
Structure and function of voltage-sensitive ion channels: W.A. Catterall; Science 242, 50 (1988), Abstract;
Molecular properties of voltage-sensitive sodium channels: W.A. Catterall; Annu. Rev. Biochem. 55, 953 (1986), Abstract;
Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes: W.A. Catterall; Annu. Rev. Pharmacol. Toxicol. 20, 15 (1980), Abstract;
The constituents of the ovaries of globefish. VIII. Studies on tetrodotoxin: K. Tsuda & M. Kawamura; Pharm. Bull. 1, 112 (1953), Abstract;

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