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Gambogic amide

TrkA ligand
BML-N159-0001 1 mg 130.00 USD
BML-N159-0005 5 mg 459.00 USD
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A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM (see reference S.-W. Jang, et al. 2007).

Product Details

Purity:≥95% (HPLC)
Appearance:Yellow-orange solid.
Solubility:Soluble in DMSO (20mg/ml) or ethanol (20mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Regulatory Status:RUO - Research Use Only
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Product Literature References

The TrkA agonist gambogic amide augments skeletal adaptation to mechanical loading: G. Fioravanti, et al.; Bone 147, 115908 (2021), Abstract;
Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death: S.-W. Jang, et al.; Proc. Natl. Acad. Sci. USA 104, 16329 (2007), Abstract; Full Text

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