A novel small molecule NGF mimic discovered using a cell-based chemical genetic screen for TrkA agonists. Gambogic amide selectively binds to TrkA, triggers its tyrosine phosphorylation, elicits PI3-kinase/Akt and MAPK activation, provokes neurite outgrowth in PC12 cells and prevents neuronal cell death. EC50 for antiapoptotic activity is 5nM (see reference S.-W. Jang, et al. 2007).
Product Details
| Formula: | C38H45NO7 |
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| MW: | 627.8 |
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| CAS: | 286935-60-2 |
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| Purity: | ≥95% (HPLC) |
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| Appearance: | Yellow-orange solid. |
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| Solubility: | Soluble in DMSO (20mg/ml) or ethanol (20mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
The TrkA agonist gambogic amide augments skeletal adaptation to mechanical loading: G. Fioravanti, et al.; Bone
147, 115908 (2021),
Abstract;
Gambogic amide, a selective agonist for TrkA receptor that possesses robust neurotrophic activity, prevents neuronal cell death: S.-W. Jang, et al.; Proc. Natl. Acad. Sci. USA
104, 16329 (2007),
Abstract;
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