A metal chelating ligand which displays protective effects in various neurodegenerative states. It has shown to modulate amyloid β-peptide accumulation via upregulation of metalloprotease activity. When co-administered with vitamin B12 it totally rescues lead-induced impairments of synaptic plasticity in an animal model.
Product Specification
| Alternative Name: | 5-Chloro-7-iodo-8-quinolinol |
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| Formula: | C9H5INOCl |
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| MW: | 305.5 |
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| CAS: | 130-26-7 |
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| Purity: | ≥97% (Assay) |
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| Appearance: | Tan solid. |
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| Solubility: | Soluble in DMSO (>25 mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Clioquinol and vitamin B12 (cobalamin) synergistically rescue the lead-induced impairments of synaptic plasticity in hippocampal dentate gyrus area of the anesthetized rats in vivo: W. H. Chen, et al.; Neuroscience
147, 853 (2007),
Abstract;
Differential modulation of Alzheimer's disease amyloid beta-peptide accumulation by diverse classes of metal ligands: A. Caragounis, et al.; Biochem. J.
407, 435 (2007),
Abstract;
Full Text
Degradation of the Alzheimer disease amyloid beta-peptide by metal-dependent up-regulation of metalloprotease activity: A. R. White, et al.; J. Biol. Chem.
281, 17670 (2006),
Abstract;
Full Text
Clioquinol down-regulates mutant huntingtin expression in vitro and mitigates pathology in a Huntington's disease mouse model: T. Nguyen, et al.; Proc. Natl. Acad. Sci. USA
102, 11840 (2005),
Abstract;
Full Text
