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Phosphatidic acid, dioleoyl

PKC activator
 
BML-LP104-0010 10 mg 104.00 USD
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A mitogenic lipid phosphate produced via the action of phospholipase D. Mediates agonist-dependent Raf-1 translocation and activation of the MAP kinase cascade. Activates PKCζ.

Product Specification

Alternative Name:1,2-Dioleoyl-sn-glycero-3-phosphate . Na
 
Formula:C39H73O8P . Na
 
MW:724
 
CAS:108392-02-5
 
Purity:≥98% (GC)
 
Identity:Determined by IR.
 
Appearance:White powder.
 
Solubility:Soluble in chloroform.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

The recruitment of Raf-1 to membranes is mediated by direct interaction with phosphatidic acid and is independent of association with Ras: M. A. Rizzo, et al.; J. Biol. Chem. 275, 23911 (2000), Abstract; Full Text
Phospholipase D and its product, phosphatidic acid, mediate agonist-dependent raf-1 translocation to the plasma membrane and the activation of the mitogen-activated protein kinase pathway: M. A. Rizzo, et al.; J. Biol. Chem. 274, 1131 (1999), Abstract;
A role for phospholipase D in control of mitogenesis: M. R. Boarder, et al.; Trends Pharmacol Sci. 15, 57 (1994), Abstract;
Phosphatidic acid activation of protein kinase C-zeta overexpressed in COS cells: comparison with other protein kinase C isotypes and other acidic lipids: C. Limatola; Biochem. J. 304, 1001 (1994), Abstract;

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