L-NASPA is an antagonist of LPA-induced platelet aggregation and chloride conductance in Xenopus oocytes. In human breast carcinoma MDA-MB231 cells it is a potent LPA agonist.
Product Details
| Alternative Name: | N-Palmitoyl-L-serine phosphoric acid |
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| Formula: | C19H38NO7P . H2O |
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| MW: | 440.5 |
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| CAS: | 155915-46-1 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (10 mg/ml)or ethanol (10 mg/ml). |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Store, as supplied, at -80°C for up to 1 year. Store solutions at -20°C for up to 1 year. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Characterization of a receptor subtype-selective lysophosphatidic acid mimetic: S. B. Hooks, et al.; Mol. Pharmacol.
53, 188 (1998),
Abstract;
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N-palmitoyl-serine and N-palmitoyl-tyrosine phosphoric acids are selective competitive antagonists of the lysophosphatidic acid receptors: K. Liliom, et al.; Mol. Pharmacol.
50, 616 (1996),
Abstract;
Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factor: T. Sugiura, et al.; Arch. Biochem. Biophys.
311, 358 (1994),
Abstract;
