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Lysophosphatidic acid

LPA receptor ligand
 
BML-LP100-0005 5 mg 75.00 USD
 
BML-LP100-0025 25 mg 275.00 USD
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Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid messenger. LPA stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes. It acts as a proliferative and anti-apoptotic factor. Ligand for LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors. It also inhibits differentiation of neural stem cells into neurons.

Product Specification

Alternative Name:1-Oleoyl-lysophosphatidic acid . sodium salt
 
Formula:C21H40O7P . Na
 
MW:458.5
 
CAS:325465-93-8
 
Purity:≥98% (TLC)
 
Appearance:Waxy solid.
 
Solubility:Soluble in water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm).
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Store as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

LPA-induced migration of ovarian cancer cells requires activation of ERM proteins via LPA1 and LPA2: J, Park, et al.; Cell. Signal. 44, 138 (2018), Abstract;
A label-free impedance-based whole cell assay revealed a new G protein-coupled receptor ligand for mouse microglial cell migration: Y. Fukano, et al.; Biochem. Biophys. Res. Commun. 478, 624 (2016), Application(s): Responses of mouse microglial MG5 cells toward GPCR ligands, Abstract;
Chitinase 3-like 1 expression by human (MG63) osteoblasts in response to lysophosphatidic acid and 1,25-dihydroxyvitamin D3: J.P. Mansell, et al.; Biochimie 128-129, 193 (2016), Application(s): Treatment with human osteoblast-like cells (MG63), Abstract;
Constitutive and Inducible Expression of Invasion-related Factors in PC-3 Prostate Cancer Cells: Y.S. Hwang, et al.; J. Cancer Prev. 20, 121 (2015), Application(s): Cell Culture, Abstract; Full Text

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