Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid messenger. LPA stimulates the growth of a variety of cells including fibroblasts, vascular smooth muscle cells, endothelial cells and keratinocytes. It acts as a proliferative and anti-apoptotic factor. Ligand for LPA1 (EDG-2), LPA2 (EDG-4) and LPA3 (EDG-7) receptors. It also inhibits differentiation of neural stem cells into neurons.
Product Details
| Alternative Name: | 1-Oleoyl-lysophosphatidic acid . sodium salt |
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| Formula: | C21H40O7P . Na |
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| MW: | 458.5 |
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| CAS: | 325465-93-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Waxy solid. |
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| Solubility: | Soluble in water (5 mg/mL with sonication) or DMSO (0.5 mg/mL warm). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store as supplied at -20°C for up to 1 year. Store solutions at -20°C for up to 1 month. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
LPA-induced migration of ovarian cancer cells requires activation of ERM proteins via LPA1 and LPA2: J, Park, et al.; Cell. Signal.
44, 138 (2018),
Abstract;
A label-free impedance-based whole cell assay revealed a new G protein-coupled receptor ligand for mouse microglial cell migration: Y. Fukano, et al.; Biochem. Biophys. Res. Commun.
478, 624 (2016),
Application(s): Responses of mouse microglial MG5 cells toward GPCR ligands,
Abstract;
Chitinase 3-like 1 expression by human (MG63) osteoblasts in response to lysophosphatidic acid and 1,25-dihydroxyvitamin D3: J.P. Mansell, et al.; Biochimie
128-129, 193 (2016),
Application(s): Treatment with human osteoblast-like cells (MG63),
Abstract;
Constitutive and Inducible Expression of Invasion-related Factors in PC-3 Prostate Cancer Cells: Y.S. Hwang, et al.; J. Cancer Prev.
20, 121 (2015),
Application(s): Cell Culture,
Abstract;
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