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N-Acetyl-leukotriene E4

 
BML-LEA004-0050 50 µg 278.00 USD
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Major bilary metabolite of cysteinyl leukotrienes in the rat. Approximately 100-fold less active than LTC4. Equiactive with LTE4 in guinea pig lung parenchyma assay.

Product Specification

Alternative Name:N-Acetyl-LTE4
 
Formula:C25H39NO6S
 
MW:481.7
 
CAS:80115-95-3
 
Concentration:50 µg/ml
 
Formulation:Solution in methanol/ammonium acetate buffer, 70:30.
 
Purity:≥98% (HPLC)
 
Appearance:Liquid.
 
Solubility:Soluble in ethanol.
 
Shipping:Shipped on Dry Ice
 
Long Term Storage:-80°C
 
Use/Stability:Store, as supplied, at -80°C for up to 1 year.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Pharmacological profile of leukotrienes E4, N-acetyl E4 and of four of their novel omega- and beta-oxidative metabolites in airways of guinea-pig and man in vitro: M.N. Samhoun, et al.; Br. J. Pharmacol. 98, 1406 (1989), Abstract; Full Text
Identification of the major endogenous leukotriene metabolite in the bile of rats as N-acetyl leukotriene E4: W. Hagmann, et al.; Prostaglandins 31, 239 (1986), Abstract;
The synthesis of N-acetyl-leukotriene E4 and its effects on cardiovascular and respiratory function of the anesthetized pig: A. Foster, et al.; Prostaglandins 31, 1077 (1986), Abstract;
Leukotrienes as mediators in tissue trauma: C. Denzlinger, et al.; Science 230, 330 (1985), Abstract;
Production of peptide leukotrienes in endotoxin shock: W. Hagmann, et al.; FEBS Lett. 180, 309 (1985), Abstract;

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