Major bilary metabolite of cysteinyl leukotrienes in the rat. Approximately 100-fold less active than LTC4. Equiactive with LTE4 in guinea pig lung parenchyma assay.
Product Specification
| Alternative Name: | N-Acetyl-LTE4 |
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| Formula: | C25H39NO6S |
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| MW: | 481.7 |
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| CAS: | 80115-95-3 |
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| Concentration: | 50 µg/ml |
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| Formulation: | Solution in methanol/ammonium acetate buffer, 70:30. |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Liquid. |
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| Solubility: | Soluble in ethanol. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Store, as supplied, at -80°C for up to 1 year. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Pharmacological profile of leukotrienes E4, N-acetyl E4 and of four of their novel omega- and beta-oxidative metabolites in airways of guinea-pig and man in vitro: M.N. Samhoun, et al.; Br. J. Pharmacol.
98, 1406 (1989),
Abstract;
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Identification of the major endogenous leukotriene metabolite in the bile of rats as N-acetyl leukotriene E4: W. Hagmann, et al.; Prostaglandins
31, 239 (1986),
Abstract;
The synthesis of N-acetyl-leukotriene E4 and its effects on cardiovascular and respiratory function of the anesthetized pig: A. Foster, et al.; Prostaglandins
31, 1077 (1986),
Abstract;
Leukotrienes as mediators in tissue trauma: C. Denzlinger, et al.; Science
230, 330 (1985),
Abstract;
Production of peptide leukotrienes in endotoxin shock: W. Hagmann, et al.; FEBS Lett.
180, 309 (1985),
Abstract;
