Biosynthesis in leukocytes, burned skin and lung lavages of patients with adult respiratory distress syndrome. Displays an uncoupling effect on mitochondrial respiration and potent relaxation of rat stomach smooth muscle. Effects in the cardiovascular system include circulatory collapse, cardiac failure, vasoconstriction and endothelial cell damage.
Product Specification
| Alternative Name: | (±)9,10-Epoxyoctadec-12Z-enoic acid |
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| Formula: | C18H32O3 |
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| MW: | 296.5 |
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| CAS: | 16833-56-0 |
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| Concentration: | 50µg/ml |
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| Formulation: | Solution in ethanol. |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Liquid. |
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| Shipping: | Shipped on Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Direct cardiovascular actions of two metabolites of linoleic acid: M. R. Siegfried, et al.; Life Sciences
46, 427 (1990),
Abstract;
Cardiovascular effects of leukotoxin (9, 10-epoxy-12-octadecenoate) and free fatty acids in dogs: A. Fukushima, et al.; Cardiovasc. Res.
22, 213 (1988),
Abstract;
Existence of leukotoxin 9,10-epoxy-12-octadecenoate in lung lavages from rats breathing pure oxygen and from patients with the adult respiratory distress syndrome: T. Ozawa, et al.; Am. Rev. Resp. Dis.
137, 535 (1988),
Abstract;
Biosynthesis of leukotoxin, 9,10-epoxy-12 octadecenoate, by leukocytes in lung lavages of rat after exposure to hyperoxia: T. Ozawa, et al.; Biochem. Biophys. Res. Commun.
134, 1071 (1986),
Abstract;
Duchenne muscular dystrophy in Wales: a 15 year study, 1971 to 1986: S. Sugiyama, et al.; Life Sciences
40, 225 (1986),
Abstract;
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