Less potent than LTD4 in smooth muscle contractile activity and mucus secretion in airways. Reduces myocardial contractility and coronary blood flow. Induces long lasting hypotension and airway hyperresponsiveness. Partial agonist at LTD4 receptors. LTE4 solely activates a CysLT1 receptor. Biosynthesis from LTD4 by a dipeptidase.
Product Details
| Alternative Name: | LTE4 |
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| Formula: | C23H37NO5S |
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| MW: | 439.6 |
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| CAS: | 75715-89-8 |
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| Concentration: | 50 µg/ml |
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| Formulation: | Solution in ethanol. |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Liquid. |
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| Shipping: | Dry Ice |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Store, as supplied, at -80°C for up to 1 year. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Airway responsiveness to histamine and leukotriene E4 in subjects with aspirin-induced asthma: J.P. Arm, et al.; Am. Rev. Resp. Dis.
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Mechanisms of leukotriene E4 partial agonist activity at leukotriene D4 receptors in differentiated U-937 cells: D.L. Saussy, et al.; J. Biol. Chem.
264, 19845 (1989),
Abstract;
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Allergen challenge of lung tissue from asthmatics elicits bronchial contraction that correlates with the release of leukotrienes C4, D4, and E4: S.-E. Dahlen, et al.; Proc. Natl. Acad. Sci. USA
80, 1712 (1983),
Abstract;
Full Text
Slow-reacting substances, leukotrienes C4 and D4, increase the release of mucus from human airways in vitro: Z. Marom, et al.; Am. Rev. Resp. Dis.
126, 449 (1982),
Abstract;
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response: S.-E. Dahlen, et al.; Proc. Natl. Acad. Sci. USA
78, 3887 (1981),
Abstract;
Full Text
Comparative airway and vascular activities of leukotrienes C-1 and D in vivo and in vitro: J.M. Drazen, et al.; Proc. Natl. Acad. Sci. USA
77, 4354 (1980),
Abstract;
Full Text
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