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Leukotriene D4

Prostanoid receptor ligand
BML-LD004-0050 50 µg 340.00 USD
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Potent agonist for contraction of smooth muscle. Induces microvascular permeability and mucus secretion in airways. Enhances growth of human airway epithelial cells. Reduces myocardial contractility and coronary blood flow. Induces long lasting hypotension. Biosynthesis from LTC4 by γ-glutamyltranspeptidase.

Product Details

Alternative Name:LTD4
Concentration:50 µg/ml
Formulation:Solution in methanol/ammonium acetate buffer, 70:30, pH 5.6.
Purity:≥98% (HPLC)
Shipping:Dry Ice
Long Term Storage:-80°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -80°C. Protect from exposure to air.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Cysteinyl leukotrienes in asthma: old mediators up to new tricks: D. W. P. Hay, et al.; Trends Pharmacol. 16, 304 (1995), Abstract;
Leukotrienes and inflammation: S. D. Brain & T. J. Williams; Pharmacol. Ther. 46, 57 (1990), Abstract;
The signal transduction system of the leukotriene D4 receptor: S. T. Crooke, et al.; Trends Pharmacol. Sci. 10, 103 (1989), Abstract;
Leukotrienes as mediators of ischemia and shock: A. M. Lefer, et al.; Biochem. Pharmacol. 35, 123 (1986), Abstract;
Metabolism of leukotrienes: S. Hammarström, et al.; Mol. Cell Biochem. 69, 7 (1985), Abstract;

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