Most potent member of the ginkgolide family of PAF antagonists. Ginkgolide B accelerates PAF hydrolysis by promoting PAF-AH I α2 homodimer activity. Inhibits PAF-induced PMNL chemotaxis (IC50=490 nM). Orally effective against PAF-induced bronchospasm.
Product Details
| Alternative Name: | BN 52021 |
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| Formula: | C20H24O10 |
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| MW: | 424.4 |
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| CAS: | 15291-77-7 |
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| Purity: | ≥90% (HPLC) |
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| Appearance: | White crystalline powder. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (2mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit: F. Bonin, et al.; J. Biol. Chem.
279, 52425 (2004),
Abstract;
Full Text
Antagonism of the platelet activating factor-induced rise of the intracellular calcium ion concentration of U937 cells: S. G. Ward, et al.; Br. J. Pharmacol.
93, 769 (1988),
Abstract;
Full Text
Platelet-activating factor primes neutrophil responses to agonists: role in promoting neutrophil-mediated endothelial damage: G. M. Vercelloti, et al.; Blood
71, 1100 (1988),
Abstract;
Full Text
Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects: N. Tamura, et al.; Biochem. Biophys. Res. Commun.
142, 638 (1987),
Abstract;
Interference of BN 52021 (ginkgolide B) with the bronchopulmonary effects of PAF-acether in the guinea-pig: S. Desquand, et al.; Eur. J. Pharmacol.
127, 83 (1986),
Abstract;
Specific inhibition of PAF-acether-induced platelet activation by BN 52021 and comparison with the PAF-acether inhibitors kadsurenone and CV 3988: D. Nunez, et al.; Eur. J. Pharmacol.
123, 197 (1986),
Abstract;
