Binds to rabbit platelet PAF receptors with high affinity. Inhibits PAF-induced platelet aggregation in rabbits (IC50=7.7 µM), bronchoconstriction in guinea-pigs, hypotension in rats and lethality in mice. Inhibits endotoxin-induced gastrointestinal damage (known to be due to PAF). Does not inhibit PAF-induced contraction of guinea pig lung parenchymal strips. Clinically useful spasmolytic agent for the control of increased tone or motility of the gut.
Product Specification
| Alternative Name: | Otilonium bromide |
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| Formula: | C29H43N2O4Br |
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| MW: | 563.6 |
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| CAS: | 26095-59-0 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (12 mg/ml), DMSO (>25 mg/ml) or ethanol (>25 mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Octylonium bromide, an antagonist of platelet-activating factor: A. Subissi, et al.; Arch. Int. Pharmacodyn.
302, 255 (1989),
Abstract;
Further studies on the pharmacodynamic properties and organ selectivity of octylonium bromide: S. Manzini, et al.; Drugs Exp. Clin. Res.
14, 265 (1988),
Abstract;
