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Octylonium bromide

PAF receptor inhibitor
BML-L131-0005 5 mg 89.00 USD
BML-L131-0025 25 mg 347.00 USD
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Binds to rabbit platelet PAF receptors with high affinity. Inhibits PAF-induced platelet aggregation in rabbits (IC50=7.7 µM), bronchoconstriction in guinea-pigs, hypotension in rats and lethality in mice. Inhibits endotoxin-induced gastrointestinal damage (known to be due to PAF). Does not inhibit PAF-induced contraction of guinea pig lung parenchymal strips. Clinically useful spasmolytic agent for the control of increased tone or motility of the gut.

Product Details

Alternative Name:Otilonium bromide
Purity:≥98% (TLC)
Appearance:White to off-white solid.
Solubility:Soluble in water (12 mg/ml), DMSO (>25 mg/ml) or ethanol (>25 mg/ml).
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year. Store solutions at -20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Octylonium bromide, an antagonist of platelet-activating factor: A. Subissi, et al.; Arch. Int. Pharmacodyn. 302, 255 (1989), Abstract;
Further studies on the pharmacodynamic properties and organ selectivity of octylonium bromide: S. Manzini, et al.; Drugs Exp. Clin. Res. 14, 265 (1988), Abstract;