Inhibits PAF-induced platelet aggregation (IC50=8.4 µM) and collagen-induced aggregation (IC50=84.2 µM) with no effect on arachidonic acid or ADP induced aggregation. Inhibits PAF-induced bronchoconstriction in vivo in the guinea-pig (69% at 1.0 mg/kg).
Product Details
| Alternative Name: | FR-49175 |
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| Formula: | C15H20N2O4S2 |
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| MW: | 356.5 |
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| CAS: | 74149-38-5 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) and ethanol (25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20ºC for up to 1 year. Store solutions at -20ºC for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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167, 1106 (2021),
Abstract;
NF-kappaB activation is a critical regulator of human granulocyte apoptosis in vitro: C. Ward, et al.; J. Biol. Chem.
274, 4309 (1999),
Abstract;
The immunosuppressive fungal metabolite gliotoxin specifically inhibits transcription factor NF-kappaB: H.L. Pahl, et al.; J. Exp. Med.
183, 1829 (1996),
Abstract;
Studies of platelet activating factor (PAF) antagonists from microbial products. I. Bisdethiobis(methylthio)gliotoxin and its derivatives: M. Okamoto, et al.; Chem. Pharm. Bull. (Tokyo)
34, 340 (1986),
Abstract;
Studies of platelet activating factor (PAF) antagonists from microbial products. II. Pharmacological studies of FR-49175 in animal models: M. Okamoto, et al.; Chem. Pharm. Bull. (Tokyo)
34, 345 (1986),
Abstract;
