Replaces Prod. #: ALX-301-010
Biologically potent, non-metabolizable analog of platelet-activating factor (PAF). Induces half-maximal PMNL degranulation response at 16nM and binds stereospecifically to high and low affinity PAF receptors. Completely resists inactivation by acetylhydrolase.
Product Details
| Alternative Name: | 1-O-Hexadecyl-2-N-methylcarbamyl-sn-glycero-3-phosphocholine |
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| Formula: | C26H55N2O7P |
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| MW: | 538.7 |
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| CAS: | 91575-58-5 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in 100% ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Ethanol stock solutions are stable for up to 3 months at -20°C. Aqueous solutions should be prepared fresh daily. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
PAF-acether transfer activity in HL-60 cells is induced during differentiation: R.H. Lumb, et al.; Biochem. Biophys. Res. Commun.
171, 548 (1990),
Abstract;
Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites: T.G. Tessner, et al.; J. Biol. Chem.
264, 4794 (1989),
Abstract;
1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor: J.T. O'Flaherty, et al.; Biochem. Biophys. Res. Commun.
147, 18 (1987),
Abstract;
