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Carbamyl-PAF

PAF receptor activator
 
BML-L120-0005 5 mg 293.00 USD
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Replaces Prod. #: ALX-301-010

Biologically potent, non-metabolizable analog of platelet-activating factor (PAF). Induces half-maximal PMNL degranulation response at 16nM and binds stereospecifically to high and low affinity PAF receptors. Completely resists inactivation by acetylhydrolase.

Product Specification

Alternative Name:1-O-Hexadecyl-2-N-methylcarbamyl-sn-glycero-3-phosphocholine
 
Formula:C26H55N2O7P
 
MW:538.7
 
CAS:91575-58-5
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in 100% ethanol.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Ethanol stock solutions are stable for up to 3 months at -20°C. Aqueous solutions should be prepared fresh daily.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

PAF-acether transfer activity in HL-60 cells is induced during differentiation: R.H. Lumb, et al.; Biochem. Biophys. Res. Commun. 171, 548 (1990), Abstract;
Stimulation of platelet-activating factor synthesis by a nonmetabolizable bioactive analog of platelet-activating factor and influence of arachidonic acid metabolites: T.G. Tessner, et al.; J. Biol. Chem. 264, 4794 (1989), Abstract;
1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor: J.T. O'Flaherty, et al.; Biochem. Biophys. Res. Commun. 147, 18 (1987), Abstract;

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