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1-O-Hexadecyl-2-O-acetyl-sn-glycero-3-phosphorylcholine

PAF receptor ligand
 
BML-L100-0005 5 mg 69.00 USD
 
BML-L100-0025 25 mg 261.00 USD
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Replaces Prod. #: ALX-301-001

Platelet activating factor (PAF) with a C16 alkyl group. Initiates receptor-mediated responses in platelets and a variety of other cells. Rabbit platelet PAF receptor KD=0.1 nM. EC50 for stimulation of phosphoinositide metabolism in hippocampal cell line: 1.2-1.5 nM.

Product Specification

Alternative Name:PAF C-16
 
Formula:C26H54NO7P
 
MW:523.7
 
CAS:74389-68-7
 
MI:14: 7524
 
Purity:≥98% (TLC)
 
Appearance:White solid.
 
Solubility:Soluble in 100% ethanol (>100 mg/ml). Soluble in water (>100mg/ml) after sonication for 1 minute at 40°C.
 
Shipping:Ambient
 
Long Term Storage:-20°C
 
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 2 months at -20°C.
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Biotinylated heptapeptides substituted with a d-amino acid as platelet-activating factor inhibitors: A. Sato, et al.; Eur. J. Pharmacol. 764, 202 (2015), Application(s): Injection into rat hind paw, Spectroscopy, Abstract;
Blood cardiolipin in haemodialysis patients. Its implication in the biological action of platelet-activating factor: S. Antonopoulou, et al.; Int. J. Biochem. Cell Biol. 28, 43 (1996), Abstract;
Guanine nucleotide regulatory proteins, Gq and Gi1/2, mediate platelet-activating factor-stimulated phosphoinositide metabolism in immortalized hippocampal cells: L.C. Shi, et al.; J. Neurochem. 67, 1478 (1996), Abstract;

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