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FLUOR DE LYS®-SIRT2 deacetylase substrate

BML-KI179-0005 0.5 µmol 245.00 USD
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FLUOR DE LYS®-SIRT2 is a fluorogenic peptide substrate for SIRT2 (human Sirtuin 2). Based on residues 317-320 of p53 (Gln-Pro-Lys-Lys(Ac)), a site of regulatory acetylation by the PCAF acetyltransferase (lysine 320), it was the best for SIRT2 from among a panel of substrates patterned on p53, Histone H3, and Histone H4 acetylation sites. FLUOR DE LYS®-SIRT2 deacetylase substrate is deacetylated by SIRT2 at a rate of more than 50-fold that of the acetylated lysine substrate (Prod. No. BML-KI104; acetylated substrates both at 25 µM, 500 µM NAD+). Must be used in conjunction with FLUOR DE LYS® Developer II (Prod. No. BML-KI176). Sufficient for 100 assays of human recombinant SIRT2 (Prod. No. BML-SE251; 2U/well, 100 µM substrate).

Product Details

Formulation:Supplied as a 5mM solution (100 µl) in HDAC Assay Buffer.
Purity:≥95% (HPLC)
Shipping:Dry Ice
Long Term Storage:-80°C
Regulatory Status:RUO - Research Use Only

Product Literature References

High-throughput screening of histone deacetylases and determination of kinetic parameters using fluorogenic assays: C. Moreno-Yruela, et al.; STAR Protoc. 2, 100313 (2021), Application(s): HTS protocol to identify deacylase activities, Abstract; Full Text
The Contribution of Romidepsin to the Herbicidal Activity of Burkholderia rinojensis Biopesticide: D.K. Owens, et al.; J. Nat. Prod. 83, 843 (2020), Abstract;
Identification of Diketopiperazine-Containing 2-Anilinobenzamides as Potent Sirtuin 2 (SIRT2)-Selective Inhibitors Targeting the "Selectivity Pocket", Substrate-Binding Site, and NAD+-Binding Site: P. Mellini, et al.; J. Med. Chem. 62, 5844 (2019), Abstract;
Pharmacophore modeling and virtual screening studies to identify novel selective SIRT2 inhibitors: G. Eren, et al.; J. Mol. Graph. Model. 10, 1313 (2019), Abstract;

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