A novel and selective HERG K+ channel activator (EC50=10.5 µM). Activates ERG2 channels. Displays antiarrhythmic properties in rabbit models.
Product Details
| Alternative Name: | N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl] urea |
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| Formula: | C15H10F6N2O3 |
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| MW: | 380.2 |
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| CAS: | 448895-37-2 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid |
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| Solubility: | Soluble in DMSO (25mg/ml) or ethanol (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Antiarrhythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome: T.G. Diness, et al.; Cardiovasc. Res.
79, 61 (2008),
Abstract;
Activation of ERG2 potassium channels by the diphenylurea NS1643: P. Elmedyb, et al.; Neuropharmacology
53, 283 (2007),
Abstract;
Activation of human ether-a-go-go-related gene potassium channels by the diphenylurea 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea (NS1643): R.S. Hansen, et al.; Mol. Pharmacol.
69, 266 (2006),
Abstract;
