PCO 400 is an analog of cromakalim (KATP) channels. It is a potent and selective opener of ATP-sensitive K+ (KATP) channels.
Product Details
| Alternative Name: | (-)-(3S,4R)-3,4-Dihydro-3-hydroxy-2,2-dimethyl-4-(3-oxocyclopent-1-enyl-1-oxy)-2H-1-benzpyran-6-carbonitrile |
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| Formula: | C17H17NO4 |
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| MW: | 299.3 |
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| CAS: | 121055-10-5 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid |
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| MeltingPoint: | 154-156°C |
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| Solubility: | Soluble in ethanol (30 mg/ml) and DMSO (>200 mg/ml). |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at -20°C for up to 3 months |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Analysis of the relaxant action of SDZ PCO 400 in airway smooth muscle from the ox and guinea-pig: R. C. Small, et al.; Eur. J. Pharmacol.
219, 81 (1992),
Abstract;
Effects of a potassium channel opener (SDZ PCO 400) on guinea-pig and human pulmonary airways: I. D. Chapman, et al.; Br. J. Pharmacol.
106, 423 (1992),
Abstract;
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