Replaces Prod. #: ALX-550-259
A selective ATP-sensitive K+ (KATP) channel opener. It is the active metabolite of minoxidil (Prod. No. BML-KC125) and is a potent (IC50=0.14 µM) vascular smooth muscle relaxant. Antihypertensive. Stimulates renin secretion.
Product Details
| Alternative Name: | U-58838 |
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| Formula: | C9H15N5O4S |
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| MW: | 289.3 |
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| CAS: | 83701-22-8 |
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| Purity: | ≥98% |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Make solution fresh before use. |
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| Technical Info/Product Notes: | Minoxidil sulfate will slowly convert to minoxidil in DMSO solutions. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Effect of minoxidil sulfate and pinacidil on single potassium channel current in cultured human outer root sheath cells and dermal papilla cells: Y. Nakaya, et al.; J. Dermatol. Sci.
7, S104 (1994),
Abstract;
A specific binding site for K+ channel openers in rat aorta: K.M. Bray & U. Quast; J. Biol. Chem.
267, 11689 (1992),
Abstract;
Clinical pharmacology of potassium channel openers: K.E. Andersson; Pharmacol. Toxicol.
70, 244 (1992),
Abstract;
K+ channel openers and insulin release: P. Lebrun, et al.; Life Sci.
51, 795 (1992),
Abstract;
R.C. Gadwood & V.C. Fiedler; Ann. Rep. Med. Chem. 24, 187 (1989),
Glyburide blocks the relaxation response to BRL 34915 (cromakalim), minoxidil sulfate and diazoxide in vascular smooth muscle: R.J. Winquist, et al.; J. Pharmacol. Exp. Ther.
248, 149 (1989),
Abstract;
Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability: K.D. Meisheri, et al.; J. Pharmacol. Exp. Ther.
245, 751 (1988),
Abstract;
