Replaces Prod. #: ALX-550-258
A selective ATP-sensitive K+ (KATP) channel opener. It is metabolized to the more active sulfate in vivo. A clinically useful anti-alopecia. Antihypertensive. Stimulates renin secretion. Potent vascular smooth muscle relaxant.
Product Details
| Alternative Name: | U-10858 |
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| Formula: | C9H15N5O |
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| MW: | 209.3 |
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| CAS: | 38304-91-5 |
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| MI: | 14: 6203 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in 100% ethanol (29mg/ml), DMSO (6.5mg/ml) or water (2.2mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Possible presence of the ATP-sensitive K+ channel in isolated spinal dorsal horn neurons of the rat: S. Yamashita, et al.; Neurosci. Lett.
170, 208 (1994),
Abstract;
Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil: K.D. Meisheri, et al.; Biochem. Pharmacol.
45, 271 (1993),
Abstract;
Potassium channel conductance as a control mechanism in hair follicles: A.E. Buhl, et al.; J. Invest. Dermatol.
101, 148S (1993),
Abstract;
Minoxidil specifically decreases the expression of lysine hydroxylase in cultured human skin fibroblasts: T. Hautala, et al.; Biochem. J.
283, 51 (1992),
Abstract;
Chapter 20. Pathogenesis and Treatment of Alopecias: R.C. Gadwood & V.C. Fiedler; Ann. Rep. Med. Chem. 24, 187 (1989),
Mechanism of action of minoxidil sulfate-induced vasodilation: a role for increased K+ permeability: K.D. Meisheri, et al.; J. Pharmacol. Exp. Ther.
245, 751 (1988),
Abstract;
Minoxidil: a review of its pharmacological properties and therapeutic use: V.M. Campese; Drugs
22, 257 (1981),
Abstract;
