Replaces Prod. #: ALX-550-270
ATP-dependent K+ channel blocker in the pancreas, which in turn causes intracellular Ca2+ levels to rise and for insulin to be secreted. It blocks vascular smooth muscle relaxation produced by KATP channel openers. Antidiabetic. High affinity binding sites have been identified in the cardiovascular system, the CNS, and pancreatic beta cells. It displays a large potency difference in pancreatic tissue (IC50 in the nM range) versus vascular tissue (IC50 in the µM range).
Product Details
| Alternative Name: | Glibenclamide |
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| Formula: | C23H28ClN3O5S |
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| MW: | 494.0 |
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| CAS: | 10238-21-8 |
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| MI: | 14: 4478 |
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| RTECS: | YS4725200 |
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| Purity: | ≥98% (Assay) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (5mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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