13(S)-Hydroxyoctadeca-9Z,11E-dienoic acid

Inhibits thromboxane production in human platelets



BML-HO013-0050	50 µg	95.00 USD

BML-HO013-1000	1 mg	919.00 USD
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Biosynthesis in rabbit peritoneal serous membranes, atherosclerotic plaques, healthy blood vessels, psoriatic skin, endothelial cells. Stimulates prostacyclin production by endothelial cells. Inhibits thromboxane production in human platelets. Inhibits platelet and tumor cell adhesion to endothelium. Antagonizes 12-HETE-induced tumor cell adhesion to endothelium. Stimulates DNA synthesis in BALB/c 3T3 fibroblasts.

Product Details

Alternative Name:	13(S)-HODE

Formula:	C₁₈H₃₂O₃

MW:	296.5

Source:	Synthetic.

CAS:	29623-28-7

Concentration:	50 µg/ml

Formulation:	Solution in ethanol.

Purity:	≥99% (HPLC)

Appearance:	Clear to light-yellow liquid.

Shipping:	Shipped on Dry Ice

Long Term Storage:	-80°C

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Cyclic AMP regulation of endothelial cell triacylglycerol turnover, 13-hydroxyoctadecadienoic acid (13-HODE) synthesis and endothelial cell thrombogenicity: T. A. Haas, et al.; Biochim. Biophys. Acta 1051, 174 (1990), Abstract;

Epidermal growth factor stimulates linoleic acid metabolism in BALB/c 3T3 fibroblasts: W.C. Glasgow & T.E. Eling ; Mol. Pharmacol. 38, 503 (1990), Abstract;

Regulation of tumor cell adhesion by intracellular 13-HODE: 15-HETE ratio: E. Bastida, et al.; J. Lipid Mediators 2, 281 (1990), Abstract;

Bidirectional control of membrane expression and/or activation of the tumor cell IRGpIIb/IIIa receptor and tumor cell adhesion by lipoxygenase products of arachidonic acid and linoleic acid: I.M. Grossi, et al.; Cancer Res. 49, 1029 (1989), Abstract; Full Text

13-Hydroxyoctadeca-9,11-dienoic acid (13-HODE) inhibits thromboxane A2 synthesis, and stimulates 12-HETE production in human platelets: B.N.Y. Setty, et al.; Biochem. Biophys. Res. Commun. 148, 528 (1987), Abstract;

13-Hydroxyoctadecadienoic acid (13-HODE) stimulates prostacyclin production by endothelial cells: B.N.Y. Setty, et al.; Biochem. Biophys. Res. Commun. 146, 502 (1987), Abstract;

13-Hydroxyoctadecadienoic acid is the vessel wall chemorepellant factor, LOX: M.R. Buchanan, et al.; J. Biol. Chem. 260, 16056 (1985), Abstract; Full Text