Primary LTB4 metabolite produced by ω oxidation in PMNL retaining some chemotactic activity. ω oxidation is blocked by 17-ODYA.
Product Details
| Alternative Name: | 20-Hydroxy-LTB4 |
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| Formula: | C20H32O5 |
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| MW: | 352.5 |
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| Source: | Synthetic. |
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| CAS: | 79516-82-8 |
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| Concentration: | 50 µg/ml |
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| Formulation: | Solution in ethanol. |
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| Purity: | ≥99% (HPLC) |
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| Appearance: | Clear to light-yellow liquid. |
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| Shipping: | Shipped on Dry Ice |
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| Long Term Storage: | -80°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Identification and functional characterization of leukotriene B4 20-hydroxylase of human polymorphonuclear leukocytes: R. J. Soberman, et al.; Proc. Natl. Acad. Sci. USA
82, 2292 (1985),
Abstract;
Full Text
Omega-oxidation is the major pathway for the catabolism of leukotriene B4 in human polymorphonuclear leukocytes: S. Shak, et al.; J. Biol. Chem.
259, 10181 (1984),
Abstract;
Full Text
Properties of leukotriene B4 20-hydroxylase from polymorphonuclear leukocytes: W. S. Powell, et al.; J. Biol. Chem.
259, 3082 (1984),
Abstract;
Full Text
Stereospecificity of leukotriene B4 and structure-function relationships for chemotaxis of human neutrophils: C. A. Dahinden, et al.; J. Immunol.
133, 1477 (1984),
Abstract;
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