Negative control for Tubacin (tubulin acetylation inducer), a highly potent and selective, reversible, cell-permeable inhibitor of HDAC6. Concentration of niltubacin in cell culture experiments typically ranges from 2-20µM.
Product Details
| Alternative Name: | 7-(4-((2R,4R,6S)-4-((4,5-dipenyloxazol-2-ylthio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenylcarbamoyl)heptanoic acid |
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| Formula: | C41H42N2O7S |
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| MW: | 706.9 |
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| Source: | Synthetic. |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (6 mg/ml). |
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| Shipping: | Dry Ice |
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| Short Term Storage: | -20°C |
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| Long Term Storage: | -80°C |
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| Use/Stability: | Stable for at least one year after receipt when stored at -80°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
LC3A Silencing Hinders Aggresome Vimentin Cage Clearance in Primary Choroid Plexus Carcinoma: M. Nassar, et al.; Sci. Rep.
7, 8022 (2017),
Application(s): Measurement of cell index against different concentration,
Abstract;
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Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents: M. Namdar, et al.; Proc. Natl. Acad. Sci. USA
107, 20003 (2010),
Abstract;
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Histone deacetylase 6 interacts with the microtubule-associated protein tau: H. Ding, et al.; J. Neurochem.
106, 2119 (2008),
Abstract;
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Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation: S.J. Haggarty, et al.; Proc. Natl. Acad. Sci. USA
100, 4389 (2003),
Abstract;
Full Text
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