Selective HDAC6 inhibitor (IC50=0.002nM). IC50 values for other HDACs are 271, 252, 0.42, 6851 and 90.7 nM for HDACs 1,2,3,8 and 10 respectively. Potent inhibitor of the proliferation of a variety of pancreatic cancer cell lines (IC50s in the 0.1-0.6µM range).
Product Details
| Alternative Name: | N-Hydroxy-7-[5-(4-tertbutoxycarbonylaminophenyl)-3-isoxazolecarboxamido]heptanamide |
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| Formula: | C22H30N4O6 |
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| MW: | 446.5 |
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| CAS: | 1045792-66-2 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | Off-white solid. |
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| Solubility: | Soluble in DMSO (15 mg/ml). |
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| Shipping: | Ambient |
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| Short Term Storage: | -20°C |
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| Use/Stability: | Store, as supplied, at -20°C for up to one year. Store solutions at -20°C for up to 3 months. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies: D. Shen, et al.; Cell Biochem. Biophys.
60, 173 (2011),
Abstract;
Full Text
Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6
: A.P. Kozikowski, et al.; J. Med. Chem.
51, 4370 (2008),
Abstract;
Full Text
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