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HDAC6 inhibitor
BML-GR361-0001 1 mg 97.00 USD
BML-GR361-0005 5 mg 379.00 USD
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Selective HDAC6 inhibitor (IC50=0.002nM). IC50 values for other HDACs are 271, 252, 0.42, 6851 and 90.7 nM for HDACs 1,2,3,8 and 10 respectively. Potent inhibitor of the proliferation of a variety of pancreatic cancer cell lines (IC50s in the 0.1-0.6µM range).

Product Specification

Alternative Name:N-Hydroxy-7-[5-(4-tertbutoxycarbonylaminophenyl)-3-isoxazolecarboxamido]heptanamide
Purity:≥98% (TLC)
Appearance:Off-white solid.
Solubility:Soluble in DMSO (15 mg/ml).
Short Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to one year.  Store solutions at -20°C for up to 3 months.
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Product Literature References

Novel Cell- and Tissue-Based Assays for Detecting Misfolded and Aggregated Protein Accumulation Within Aggresomes and Inclusion Bodies: D. Shen, et al.; Cell Biochem. Biophys. 60, 173 (2011), Abstract; Full Text
Use of the Nitrile Oxide Cycloaddition (NOC) Reaction for Molecular Probe Generation: A New Class of Enzyme Selective Histone Deacetylase Inhibitors (HDACIs) Showing Picomolar Activity at HDAC6 : A.P. Kozikowski, et al.; J. Med. Chem. 51, 4370 (2008), Abstract; Full Text

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