The MRN-ATM pathway is essential for sensing the signaling from DNA double-strand breaks. Mirin is an inhibitor of MRN discovered using a forward chemical genetic screen. It prevents MRN-dependent activation of ATM without affecting ATM protein kinase activity and it inhibits Mre11-associated exonuclease activity. IC50=66μM. It abolishes the G2/M checkpoint and homology-dependent repair in mammalian cells.
Product Details
| Alternative Name: | Z-5-(4-Hydroxybenzylidene)-2-imino-1,3-thiazolidin-4-one |
| |
| Formula: | C10H8N2O2S |
| |
| MW: | 220.3 |
| |
| Source: | Synthetic. |
| |
| CAS: | 299953-00-7 |
| |
| Purity: | ≥95% (TLC) |
| |
| Appearance: | Yellow solid. |
| |
| Solubility: | Soluble in DMSO (25mg/ml) or DMF (25mg/ml). |
| |
| Shipping: | Blue Ice |
| |
| Long Term Storage: | -20°C |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
Corrected structure of mirin, a small-molecule inhibitor of the Mre11-Rad50-Nbs1 complex: K.M. Garner, et al.; Nat. Chem. Biol.
5, 129 (2009),
Abstract;
Reply to 'Corrected structure of mirin, a small-molecule inhibitor of the Mre11–Rad50–Nbs1 complex': S. Peterson, et al.; Nat. Chem. Biol.
5, 130 (2009),
Abstract;
A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex: A. Dupre, et al.; Nat. Chem. Biol.
4, 119 (2008),
Abstract;
