Replaces Prod. #: ALX-270-382
ITSA-1 is a cell permeable benzotriazole amide that counteracts trichostatin A (Prod. No. BML-GR309) induced cell cycle arrest, histone acetylation and transcriptional activation but not the activity of other HDAC inhibitors.
Product Details
| Alternative Name: | N-(1H-Benzotriazol-1-yl)-2,4-dichlorobenzamide |
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| Formula: | C13H7Cl2N3O |
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| MW: | 292.1 |
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| CAS: | 200626-61-5 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at room temperature. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. Packaged under inert gas. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Chemical genetic modifier screens: small molecule trichostatin suppressors as probes of intracellular histone and tubulin acetylation: K.M. Koeller, et al.; Chem. Biol.
10, 397 (2003),
Abstract;
Multidimensional chemical genetic analysis of diversity-oriented synthesis-derived deacetylase inhibitors using cell-based assays: S.J. Haggarty, et al.; Chem. Biol.
10, 383 (2003),
Abstract;
