Replaces Prod. #: ALX-270-380
Potent inhibitor of yeast NAD+-dependent histone deacetylase Sir2p (IC50=60µM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
Product Details
| Formula: | C13H10O2 |
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| MW: | 198.2 |
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| CAS: | 5690-03-9 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (>25mg/ml) or 100% ethanol (>25mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Use/Stability: | Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. Packaged under inert gas. After reconstitution, prepare aliquots and store at -20°C. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Identification and characterization of novel sirtuin inhibitor scaffolds: B.D. Sanders, et al.; Bioorg. Med. Chem.
17, 7031 (2009),
Abstract;
Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast: M. Hirao, et al.; J. Biol. Chem.
278, 52773 (2003),
Abstract;
Identification of a small molecule inhibitor of Sir2p: A. Bedalov, et al.; PNAS
98, 15113 (2001),
Abstract;
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