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HDAC inhibitor
BML-GR326-0001 1 mg 89.00 USD
BML-GR326-0005 5 mg 355.00 USD
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Replaces Prod. #: ALX-270-298

Inhibitor of histone deacetylase (HDAC) (HDAC1 and 3: IC50~0.6µM; HDAC8: IC50~1µM) with lower toxicity than trichostatin A (Prod. No. BML-GR309). Inhibits tumor growth in vitro and in vivo and, in conjunction with 5-aza-2’-deoxycytidine (Prod. No. ALX-480-096), enhances expression of estrogen receptor α. Optimal concentration 2-2.5μg/ml (6-8μM). A negative control is available (Prod. No. BML-GR327).

Product Details

Alternative Name:6-(1,3-Dioxo-1H,3H-benzo[de]isoquinolin-2-yl)-N-hydroxyhexanamide
Purity:≥97% (HPLC)
Identity:Determined by NMR.
Appearance:Yellow solid.
Solubility:Soluble in DMSO (4mg/ml), ethanol (0.3mg/ml) or methanol.
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from air. Store under inert gas
Regulatory Status:RUO - Research Use Only
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Product Literature References

Ferroptosis in Neurons and Cancer Cells Is Similar But Differentially Regulated by Histone Deacetylase Inhibitors: M. Zille, et al.; eNeuro 6, ENEURO.0263-18.2019 (2019), Abstract; Full Text
Inhibitors of histone deacetylases: correlation between isoform specificity and reactivation of HIV type 1 (HIV-1) from latently infected cells: K. Huber, et al.; J. Biol. Chem. 286, 22211 (2011), Abstract; Full Text
A novel histone deacetylase inhibitor, scriptaid, enhances expression of functional estrogen receptor alpha (ER) in ER negative human breast cancer cells in combination with 5-aza 2'-deoxycytidine: J.C. Keen, et al.; Breast Cancer Res. Treat. 81, 177 (2003), Abstract;
Identification of novel isoform-selective inhibitors within class I histone deacetylases: E. Hu, et al.; J. Pharmacol. Exp. Ther. 307, 720 (2003), Abstract;
A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library: G.H. Su, et al.; Cancer Res. 60, 3137 (2000), Abstract; Full Text

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