Replaces Prod. #: ALX-430-094
Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5.
Product Details
| Alternative Name: | 4-(3-Hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydro-4H-pyrimidin-5-carboxylic acid ethyl ester |
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| Formula: | C14H16N2O3S |
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| MW: | 292.4 |
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| CAS: | 329689-23-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to light yellow solid. |
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| MeltingPoint: | 184-186°C |
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| Solubility: | Soluble in DMSO (20mg/ml) or 100% ethanol (4mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from light. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
BubR1 allelic effects drive phenotypic heterogeneity in mosaic-variegated aneuploidy progeria syndrome: C.J. Sieben, et al.; J. Clin. Invest.
130, 171 (2020),
Abstract;
Full Text
Probing the catalytic functions of Bub1 kinase using the small molecule inhibitors BAY-320 and BAY-524: A.P. Baron, et al.; eLife
5, e12187 (2016),
Application(s): Cell culture,
Abstract;
Cytokinetic failure-induced tetraploidy develops into aneuploidy, triggering skin aging in phospho-vimentin deficient mice: H. Tanaka, et al.; J. Biol. Chem.
290, 12984 (2015),
Application(s): Cell Culture using mouse fibroblasts,
Abstract;
Full Text
Mitochondria localize to the cleavage furrow in mammalian cytokinesis: E.J. Lawrence, et al.; PLoS One
8, e72886 (2013),
Abstract;
Full Text
A pathway of structural changes produced by monastrol binding to Eg5: Z. Maliga, et al.; J. Biol. Chem.
281, 7977 (2006),
Abstract;
Allosteric inhibition of kinesin-5 modulates its processive directional motility: B.H. Kwok, et al.; Nat. Chem. Biol.
2, 480 (2006),
Abstract;
Interaction of the mitotic kinesin Eg5 inhibitor monastrol with P-glycoprotein: T. Peters, et al.; Naunyn Schmiedebergs Arch. Pharmacol.
372, 291 (2006),
Abstract;
Monastrol, a selective inhibitor of the mitotic kinesin Eg5, induces a distinctive growth profile of dendrites and axons in primary cortical neuron cultures: S.Y. Yoon, et al.; Cell Motil. Cytoskeleton
60, 181 (2005),
Abstract;
Inhibition of a mitotic motor protein: where, how, and conformational consequences: Y. Yan, et al.; J. Mol. Biol.
335, 547 (2004),
Abstract;
Evidence that monastrol is an allosteric inhibitor of the mitotic kinesin Eg5: Z. Maliga, et al.; Chem. Biol.
9, 989 (2002),
Abstract;
A combinatorial approach to recognition of chirality: preparation of highly enantioselective aryl-dihydropyrimidine selectors for chiral HPLC: K. Lewandowski, et al.; J. Comb. Chem.
1, 105 (1999),
Abstract;
Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screen: T.U. Mayer, et al.; Science
286, 971 (1999),
Abstract;
