A DNA topoisomerase I inhibitor that induces differentiation in HL-60 cells. It induces apoptosis in human breast cancer cell lines MCF-7 and MDA-MB-468.
Product Details
| Formula: | C20H16N2O5 |
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| MW: | 364.4 |
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| CAS: | 64439-81-2 |
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| Purity: | ≥97% |
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| Appearance: | Pale yellow solid. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Upregulation of p21WAF1/CIP1 in human breast cancer cell lines MCF-7 and MDA-MB-468 undergoing apoptosis induced by natural product anticancer drugs 10-hydroxycamptothecin and camptothecin through p53-dependent and independent pathways: W. Liu, et al.; Int. J. Oncol.
12, 793 (1998),
Abstract;
Differentiation induction of human promyelocytic leukemia cells by 10-hydroxycamptothecin, a DNA topoisomerase I inhibitor: Y.H. Ling, et al.; Differentiation
46, 135 (1991),
Abstract;
