A DNA-intercalating antitumor agent. Inhibits DNA topoisomerase II. Inhibits the phosphorylation of p53 in Lewis lung carcinoma cells and induces apoptosis. Inhibits cytochrome P-450-1A1.
Product Details
| Alternative Name: | 5,11-Dimethyl-6H-pyrido[4,3-b]carbazole |
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| Formula: | C17H14N2 |
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| MW: | 246.3 |
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| CAS: | 519-23-3 |
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| Purity: | ≥98% (TLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | Bright yellow solid. |
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| Solubility: | Soluble in DMSO, DMF or ethanol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Topoisomerase II binds to ellipticine in the absence or presence of DNA. Characterization of enzyme-drug interactions by fluorescence spectroscopy: S. J. Ammon-Froelich, et al.; J. Biol. Chem.
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