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Puromycin . 2HCl

Protein synthesis inhibitor



BML-GR312-0050	50 mg	64.00 USD

BML-GR312-0250	250 mg	248.00 USD
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Replaces Prod. #: ALX-380-028

Inhibits protein synthesis. Inhibits translation by causing premature release of nascent polypeptide. Induces apoptosis.

Product Specification

Alternative Name:	3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine . 2HCl, 3'-(α-Amino-p-methoxy-hydrocinnamamido-3'-deoxy-N,N-dimethyl-adenosine . 2HCl

Formula:	C₂₂H₂₉N₇O₅ . 2HCl

MW:	544.4

CAS:	58-58-2

MI:	14: 7943

RTECS:	AU7355000

Purity:	≥98% (HPLC, TLC)

Appearance:	White to off-white solid.

Solubility:	Soluble in water (50mg/ml).

Shipping:	Ambient

Long Term Storage:	-20°C

Use/Stability:	Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Handling:	Protect from moisture.

Regulatory Status:	RUO - Research Use Only

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Product Literature References

Cytokinin-induced protein synthesis suppresses growth and osmotic stress tolerance: S.S. Karunadasa, et al.; New Phytol. 227, 50 (2020), Application(s): Treatment of A. thaliana seedlings, Abstract;

NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment: S. Yoshimoto, et al.; Lab. Invest. (2020), Abstract; Full Text

Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab: C. Kowalczyk-Quintas, et al.; Front. Immunol. 9, 2698 (2018), Application(s): HEK293T cell selection after transfection, Abstract; Full Text

Mice lacking L-12/15-lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis: M.A. Kanzler, et al.; Epilepsia Open 3, 255 (2018), Application(s): Cell Culture, Abstract; Full Text

Changes in O-GlcNAc homeostasis activate the p53 pathway in ovarian cancer cells: R.M. de Queiroz, et al.; J. Biol. Chem. 291, 18897 (2016), Application(s): Cell culture, human cell lines, Abstract;

Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1: G. Harada, et al.; J. Functional Foods 23, 444 (2016), Application(s): Cell culture,

Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation: C. Zhao, et al.; Oxid. Med. Cell. Longev. 2016, 2927131 (2016), Application(s): Retrovirus Production and Transduction, Abstract; Full Text

Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model: S. Meister, et al.; J. Cereb. Blood Flow Metab. 35, 1112 (2015), Application(s): Cell Culture, Abstract;

Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools: S. Balasubramanian, et al.; J. Biotechnol. 200, 61 (2015), Application(s): Cell Culture, Abstract;

Inhibition of puromycin-induced apoptosis in breast cancer cells by IGF-I occurs simultaneously with increased protein synthesis: G. Soderlund, et al.; Neoplasma 51, 1 (2004), Abstract;

Increased Apoptosis in Acute Puromycin Aminonucleoside Nephrosis: L. Fernandez, et al.; Exp. Nephrol. 9, 99 (2001), Abstract;

Puromycin Aminonucleoside Induces Glomerular Epithelial Cell Apoptosis: V. Sanwal, et al.; Exp. Mol. Pathol. 70, 54 (2001), Abstract;

Cell proliferation and apoptosis of the glomerular epithelial cells in rats with puromycin aminonucleoside nephrosis: H. Shiiki, et al.; Pathobiology 66, 221 (1998), Abstract;

Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization: D.B. Constam, et al.; J. Biol. Chem. 270, 26931 (1995), Abstract; Full Text

Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis: S.C. Chow, et al.; Exp. Cell Res. 216, 149 (1995), Abstract;

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis: S.H. Kaufmann, et al.; Cancer Res. 53, 3976 (1993), Abstract;

Unexpected cytokinetic effects induced by puromycin include a G2- arrest, a metaphase-mitotic-arrest, and apoptosis: A.N. Davidoff & B.V. Mendelow; Leuk. Res. 16, 1077 (1992), Abstract;