Replaces Prod. #: ALX-380-028
Inhibits protein synthesis. Inhibits translation by causing premature release of nascent polypeptide. Induces apoptosis.
Product Details
| Alternative Name: | 3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine . 2HCl, 3'-(α-Amino-p-methoxy-hydrocinnamamido-3'-deoxy-N,N-dimethyl-adenosine . 2HCl |
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| Formula: | C22H29N7O5 . 2HCl |
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| MW: | 544.4 |
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| CAS: | 58-58-2 |
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| MI: | 14: 7943 |
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| RTECS: | AU7355000 |
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| Purity: | ≥98% (HPLC, TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in water (50mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | -20°C |
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| Use/Stability: | Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C. |
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| Handling: | Protect from moisture. |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence-based affinity maturation: A. Kielczewska, et al.; J. Biol. Chem.
298, 101533 (2022),
Abstract;
NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment: S. Yoshimoto, et al.; Lab. Invest.
101, 38 (2021),
Abstract;
Full Text
Cytokinin-induced protein synthesis suppresses growth and osmotic stress tolerance: S.S. Karunadasa, et al.; New Phytol.
227, 50 (2020),
Application(s): Treatment of A. thaliana seedlings,
Abstract;
Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab: C. Kowalczyk-Quintas, et al.; Front. Immunol.
9, 2698 (2018),
Application(s): HEK293T cell selection after transfection,
Abstract;
Full Text
Mice lacking L-12/15-lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis: M.A. Kanzler, et al.; Epilepsia Open
3, 255 (2018),
Application(s): Cell Culture,
Abstract;
Full Text
Changes in O-GlcNAc homeostasis activate the p53 pathway in ovarian cancer cells: R.M. de Queiroz, et al.; J. Biol. Chem.
291, 18897 (2016),
Application(s): Cell culture, human cell lines,
Abstract;
Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1: G. Harada, et al.; J. Functional Foods 23, 444 (2016), Application(s): Cell culture,
Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation: C. Zhao, et al.; Oxid. Med. Cell. Longev.
2016, 2927131 (2016),
Application(s): Retrovirus Production and Transduction,
Abstract;
Full Text
Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model: S. Meister, et al.; J. Cereb. Blood Flow Metab.
35, 1112 (2015),
Application(s): Cell Culture,
Abstract;
Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools: S. Balasubramanian, et al.; J. Biotechnol.
200, 61 (2015),
Application(s): Cell Culture,
Abstract;
Inhibition of puromycin-induced apoptosis in breast cancer cells by IGF-I occurs simultaneously with increased protein synthesis: G. Soderlund, et al.; Neoplasma
51, 1 (2004),
Abstract;
Increased Apoptosis in Acute Puromycin Aminonucleoside Nephrosis: L. Fernandez, et al.; Exp. Nephrol.
9, 99 (2001),
Abstract;
Puromycin Aminonucleoside Induces Glomerular Epithelial Cell Apoptosis: V. Sanwal, et al.; Exp. Mol. Pathol.
70, 54 (2001),
Abstract;
Cell proliferation and apoptosis of the glomerular epithelial cells in rats with puromycin aminonucleoside nephrosis: H. Shiiki, et al.; Pathobiology
66, 221 (1998),
Abstract;
Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization: D.B. Constam, et al.; J. Biol. Chem.
270, 26931 (1995),
Abstract;
Full Text
Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis: S.C. Chow, et al.; Exp. Cell Res.
216, 149 (1995),
Abstract;
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis: S.H. Kaufmann, et al.; Cancer Res.
53, 3976 (1993),
Abstract;
Unexpected cytokinetic effects induced by puromycin include a G2- arrest, a metaphase-mitotic-arrest, and apoptosis: A.N. Davidoff & B.V. Mendelow; Leuk. Res.
16, 1077 (1992),
Abstract;
