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United States 

Puromycin . 2HCl

Protein synthesis inhibitor
BML-GR312-0050 50 mg 73.00 USD
BML-GR312-0250 250 mg 287.00 USD
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Replaces Prod. #: ALX-380-028

Inhibits protein synthesis. Inhibits translation by causing premature release of nascent polypeptide. Induces apoptosis.

Product Details

Alternative Name:3'-[[2-Amino-3-(4-methoxyphenyl)-1-oxopropyl]amino]-3'-deoxy-N,N-dimethyl-adenosine . 2HCl, 3'-(α-Amino-p-methoxy-hydrocinnamamido-3'-deoxy-N,N-dimethyl-adenosine . 2HCl
Formula:C22H29N7O5 . 2HCl
MI:14: 7943
Purity:≥98% (HPLC, TLC)
Appearance:White to off-white solid.
Solubility:Soluble in water (50mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Stable for at least 1 year after receipt when stored, as supplied, at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Handling:Protect from moisture.
Regulatory Status:RUO - Research Use Only
BML-GR312 structure
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BML-GR312 structure

Product Literature References

HDAC8 Deacetylates HIF-1α and Enhances Its Protein Stability to Promote Tumor Growth and Migration in Melanoma: J.Y. Kim, et al.; Cancers (Basel) 15, 1123 (2023), Abstract;
Inhibition of DNMT3B and PI3K/AKT/mTOR and ERK Pathways as a Novel Mechanism of Volasertib on Hypomethylating Agent-Resistant Cells: E.J. Choi, et al.; Biomol. Ther. 31, 319 (2023), Abstract;
Development of a potent high-affinity human therapeutic antibody via novel application of recombination signal sequence-based affinity maturation: A. Kielczewska, et al.; J. Biol. Chem. 298, 101533 (2022), Abstract;
Effect of Clinically Used Microtubule Targeting Drugs on Viral Infection and Transport Function: M.Á. Oliva, et al.; Int. J. Mol. Sci. 23, 3448 (2022), Abstract;
Inhibition of mTORC1 differentially affects ribosome biogenesis in rat soleus muscle at the early and later stages of hindlimb unloading: S.V. Rozhkov, et al.; Arch. Biochem. Biophys. 730, 109411 (2022), Abstract;
LRH-1/NR5A2 interacts with the glucocorticoid receptor to regulate glucocorticoid resistance: S. Michalek, et al.; EMBO Rep. 23, e54195 (2022), Abstract;
The Role of Glycogen Synthase Kinase-3 in the Regulation of Ribosome Biogenesis in Rat Soleus Muscle under Disuse Conditions: S.V. Rozhkov, et al.; Int. J. Mol. Sci. 23, 2751 (2022), Abstract;
NFAT5 promotes oral squamous cell carcinoma progression in a hyperosmotic environment: S. Yoshimoto, et al.; Lab. Invest. 101, 38 (2021), Abstract; Full Text
Cytokinin-induced protein synthesis suppresses growth and osmotic stress tolerance: S.S. Karunadasa, et al.; New Phytol. 227, 50 (2020), Application(s): Treatment of A. thaliana seedlings, Abstract;
Inhibition of Membrane-Bound BAFF by the Anti-BAFF Antibody Belimumab: C. Kowalczyk-Quintas, et al.; Front. Immunol. 9, 2698 (2018), Application(s): HEK293T cell selection after transfection, Abstract; Full Text
Mice lacking L-12/15-lipoxygenase show increased mortality during kindling despite demonstrating resistance to epileptogenesis: M.A. Kanzler, et al.; Epilepsia Open 3, 255 (2018), Application(s): Cell Culture, Abstract; Full Text
Changes in O-GlcNAc homeostasis activate the p53 pathway in ovarian cancer cells: R.M. de Queiroz, et al.; J. Biol. Chem. 291, 18897 (2016), Application(s): Cell culture, human cell lines, Abstract;
Lactobacillus brevis T2102 suppresses the growth of colorectal cancer cells by activating SIRT1: G. Harada, et al.; J. Functional Foods 23, 444 (2016), Application(s): Cell culture,
Pomegranate-Derived Polyphenols Reduce Reactive Oxygen Species Production via SIRT3-Mediated SOD2 Activation: C. Zhao, et al.; Oxid. Med. Cell. Longev. 2016, 2927131 (2016), Application(s): Retrovirus Production and Transduction, Abstract; Full Text
Expression of the ALS-causing variant hSOD1G93A leads to an impaired integrity and altered regulation of claudin-5 expression in an in vitro blood-spinal cord barrier model: S. Meister, et al.; J. Cereb. Blood Flow Metab. 35, 1112 (2015), Application(s): Cell Culture, Abstract;
Rapid recombinant protein production from piggyBac transposon-mediated stable CHO cell pools: S. Balasubramanian, et al.; J. Biotechnol. 200, 61 (2015), Application(s): Cell Culture, Abstract;
Inhibition of puromycin-induced apoptosis in breast cancer cells by IGF-I occurs simultaneously with increased protein synthesis: G. Soderlund, et al.; Neoplasma 51, 1 (2004), Abstract;
Increased Apoptosis in Acute Puromycin Aminonucleoside Nephrosis: L. Fernandez, et al.; Exp. Nephrol. 9, 99 (2001), Abstract;
Puromycin Aminonucleoside Induces Glomerular Epithelial Cell Apoptosis: V. Sanwal, et al.; Exp. Mol. Pathol. 70, 54 (2001), Abstract;
Cell proliferation and apoptosis of the glomerular epithelial cells in rats with puromycin aminonucleoside nephrosis: H. Shiiki, et al.; Pathobiology 66, 221 (1998), Abstract;
Puromycin-sensitive aminopeptidase. Sequence analysis, expression, and functional characterization: D.B. Constam, et al.; J. Biol. Chem. 270, 26931 (1995), Abstract; Full Text
Reevaluation of the role of de novo protein synthesis in rat thymocyte apoptosis: S.C. Chow, et al.; Exp. Cell Res. 216, 149 (1995), Abstract;
Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis: S.H. Kaufmann, et al.; Cancer Res. 53, 3976 (1993), Abstract;
Unexpected cytokinetic effects induced by puromycin include a G2- arrest, a metaphase-mitotic-arrest, and apoptosis: A.N. Davidoff & B.V. Mendelow; Leuk. Res. 16, 1077 (1992), Abstract;

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