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Estrogen receptor β activator
BML-GR248-0050 50 mg 593.00 USD
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Selective estrogen receptor ERβ agonist displaying 70-fold greater selectivity over ERα(EC50 = 0.85 and 66nM, respectively). It displays neuroprotective activity in various in vitro and in vivo models.

Product Details

Alternative Name:Diarylpropionitrile, 2,3-bis(4-Hydroxyphenyl)-propionitrile
Purity:≥98% (TLC)
Appearance:White solid.
Solubility:Soluble in DMSO (10mg/ml) or 100% ethanol (1.5mg/ml).
Shipping:Ambient Temperature
Long Term Storage:-20°C
Use/Stability:Store, as supplied, at -20°C for up to 1 year.  Store solutions at-20°C for up to 3 months.
Regulatory Status:RUO - Research Use Only
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Product Literature References

Neuroprotective properties of selective estrogen receptor agonists in cultured neurons: M. Cordey & C.J. Pike; Brain Res. 1045, 217 (2005), Abstract;
Neuroprotection by a selective estrogen receptor beta agonist in a mouse model of global ischemia: H.V. Carswell, et al.; Am. J. Physiol. Heart Circ. Physiol. 287, H1501 (2004), Abstract;
Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues: M.J. Meyers, et al.; J. Med. Chem. 44, 4230 (2001), Abstract;