TCPOBOP is an activator of the mouse constitutive androstane receptor (CAR) and a potent inducer of cytochrome P450 monoxygenase activity. Has been shown to have a potent tumor-promoting activity and hepatocarcinogenic effects in mice but not in rats.
Product Details
| Alternative Name: | 1,4-Bis-[2-(3,5-dichloropyridyloxy)]benzene |
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| Formula: | C16H8Cl4N2O2 |
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| MW: | 402.1 |
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| Source: | Synthetic. |
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| CAS: | 76150-91-9 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (5mg/ml). |
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| Shipping: | Ambient |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Importance of hepatic induction of constitutive androstane receptor and other transcription factors that regulate xenobiotic metabolism and transport: J. S. Petrick & C. D. Klaassen; Drug Metab. Dispos.
35, 1806 (2007),
Abstract;
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Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins: E. S. Baskin-Bey, et al.; Hepatology
44, 252 (2006),
Abstract;
Tumor-promoting and hepatocarcinogenic effects of 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) in DBA/2NCr and C57BL/6NCr mice and an apparent promoting effect on nasal cavity tumors but not on hepatocellular tumors in F344/NCr rats initiated with N-nitrosodiethylamine: B. A. Diwan, et al.; Carcinogenesis
13, 1893 (1992),
Abstract;
