Potent and selective PXR agonist. (EC50=200 nM for human PXR). A weak activator of rat and mouse PXR. Inhibits cholesterol biosynthesis in a number of species.
Product Details
| Alternative Name: | Tetraethyl 2-(3,5-Di-t-butyl-4-hydroxyphenyl)ethenyl-1,1-bisphosphonate |
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| Formula: | C24H42O7P2 |
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| MW: | 504.5 |
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| Source: | Synthetic. |
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| CAS: | 126411-39-0 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White solid. |
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| Solubility: | Soluble in DMSO (25mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Chemical regulators of epithelial plasticity reveal a nuclear receptor pathway controlling myofibroblast differentiation: J.M. Carthy, et al.; Sci. Rep.
6, 29868 (2016),
Application(s): Screening of chemical compounds with HaCaT cells,
Abstract;
Full Text
3-Hydroxyflavone and structural analogues differentially activate pregnane X receptor: Implication for inflammatory bowel disease: A. Lau, et al. ; Pharmacol. Res.
100, 64 (2015),
Application(s): Ligand Binding assay,
Abstract;
The human nuclear xenobiotic receptor PXR: structural determinants of directed promiscuity: R. E. Watkins, et al.; Science
292, 2329 (2001),
Abstract;
The pregnane X receptor: a promiscuous xenobiotic receptor that has diverged during evolution: S. A. Jones, et al.; Mol. Endocrinol.
14, 27 (2000),
Abstract;
Induction of cytochrome P4503A by the antiglucocorticoid mifepristone and a novel hypocholesterolaemic drug: J. A. Williams, et al.; Drug Metab. Dispos.
25, 757 (1997),
Abstract;
SR-12813 lowers plasma cholesterol in beagle dogs by decreasing cholesterol biosynthesis: T. A. Berkhout, et al.; Atherosclerosis
133, 203 (1997),
Abstract;
The novel cholesterol-lowering drug SR-12813 inhibits cholesterol synthesis via an increased degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase: T. A. Berkhout, et al.; J. Biol. Chem.
271, 14376 (1996),
Abstract;
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