Potent and selective PPARγ antagonist. T0070907 blocks PPARγ function in both cell-based reporter gene and adipocyte differentiation assays. It inhibits growth and survival of hepatocellular carcinoma cells and squamous cell carcinoma cell lines by interfering with cell adhesion "anoikis".
Product Details
| Alternative Name: | 2-Chloro-5-nitro-N-4-pyridinylbenzamide |
| |
| Formula: | C12H8ClN3O3 |
| |
| MW: | 277.7 |
| |
| CAS: | 313516-66-4 |
| |
| Purity: | ≥98% (TLC) |
| |
| Appearance: | Off-white solid. |
| |
| Solubility: | Soluble in DMSO (>25 mg/ml). |
| |
| Shipping: | Ambient Temperature |
| |
| Long Term Storage: | Ambient |
| |
| Use/Stability: | Store, as supplied, at room temperature for up to 1 year. Store solutions at-20°C for up to 3 months. |
| |
| Regulatory Status: | RUO - Research Use Only |
| |
Please mouse over
Product Literature References
miR-223 Plays a Key Role in Obesogen-Enhanced Adipogenesis in Mesenchymal Stem Cells and in Transgenerational Obesity: R.C. Chang, et al.; Endocrinology
164, bqad027 (2023),
Abstract;
Cannabidiol promotes adipogenesis of human and mouse mesenchymal stem cells via PPARĪ³ by inducing lipogenesis but not lipolysis: R.C. Chang, et al.; Biochem. Pharmacol.
197, 114910 (2022),
Abstract;
Effects of Perinatal Exposure to Dibutyltin Chloride on Fat and Glucose Metabolism in Mice, and Molecular Mechanisms, in Vitro: R. Chamorro-Garcia, et al.; Environ. Health Perspect.
126, 057006 (2018),
Abstract;
Full Text
Critical role of peroxisome proliferator-activated receptor gamma on anoikis and invasion of squamous cell carcinoma: T. Masuda, et al.; Clin. Cancer Res.
11, 4012 (2005),
Abstract;
Full Text
Peroxisome proliferator-activated receptor gamma inhibition prevents adhesion to the extracellular matrix and induces anoikis in hepatocellular carcinoma cells: K. L. Schaefer, et al.; Cancer Res.
65, 2251 (2005),
Abstract;
Full Text
PPARgamma antagonists exacerbate neural antigen-specific Th1 response and experimental allergic encephalomyelitis: H. P. Raikwar, et al.; J. Neuroimmunol.
167, 99 (2005),
Abstract;
T0070907, a selective ligand for peroxisome proliferator-activated receptor gamma, functions as an antagonist of biochemical and cellular activities: G. Lee, et al.; J. Biol. Chem.
277, 19649 (2002),
Abstract;
Full Text
