A partial antagonist for the aryl hydrocarbon receptor. Induces apoptosis in human cancer cells. Activates cytochrome P-450 1A2.
Product Details
| Formula: | C17H14N2 |
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| MW: | 246.3 |
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| CAS: | 1968-05-4 |
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| Purity: | ≥98% (HPLC) |
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| Appearance: | Off-white powder. |
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| Solubility: | Soluble in DMSO. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | +4°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Agonist and chemopreventative ligands induce differential transcriptional cofactor recruitment by aryl hydrocarbon receptor: E. V. Hestermann & M. Brown; Mol. Cell. Biol.
23, 7920 (2003),
Abstract;
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3,3'-Diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices: B. G. Lake, et al.; Xenobiotica
28, 803 (1998),
Abstract;
Indole-3-carbinol and diindolylmethane as aryl hydrocarbon (Ah) receptor agonists and antagonists in T47D human breast cancer cells: I. Chen, et al.; Biochem. Pharmacol.
51, 1069 (1996),
Abstract;
