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WY-14643

PPAR ligand
 
BML-GR200-0050 50 mg 100.00 USD
 
BML-GR200-0250 250 mg 396.00 USD
Do you need bulk/larger quantities?
 
Replaces Prod. #: ALX-270-198

WY-14643 is a potent and widely used peroxisome proliferator activator receptor (PPAR) activator. It has been shown to be selective for PPARα.

Product Specification

Alternative Name:Pirinixic acid
 
Formula:C14H14ClN3O2S
 
MW:323.8
 
CAS:50892-23-4
 
RTECS:AG2915000
 
Purity:≥97% (HPLC)
 
Identity:Determined by NMR.
 
Appearance:White to off-white solid.
 
MeltingPoint:155-157°C
 
Solubility:Soluble in ethyl acetate or dilute base or slightly soluble in alcohol.
 
Shipping:Ambient
 
Long Term Storage:Ambient
 
Regulatory Status:RUO - Research Use Only
 
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Product Literature References

Natural helix 9 mutants of PPARĪ³ differently affect its transcriptional activity: M.F. Brokekema, et al.; Mol. Metab. 20, 115 (2019), Abstract;
CRY1/2 Selectively Repress PPARd and Limit Exercise Capacity: S.D. Jordan, et al.; Cell Metab. 26, 243 (2017), Abstract; Full Text
Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology: I.T. Bijsmans, et al.; Biochim. Biophys. Acta 1863, 687 (2016), Abstract;
PPAR alpha Activation Reduces Hepatic CEACAM1 Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition: S.K. Ramakrishnan, et al.; J. Biol. Chem. 291, 8121 (2016), Application(s): Ingested by mice, Abstract; Full Text
Systemic administration of WY-14643, a selective synthetic agonist of peroxisome proliferator activator receptor-alpha, alters spinal neuronal firing in a rodent model of neuropathic pain: B.N. Okine, et al.; Scand. J. Pain. 9, 42 (2015), Application(s): Intraperitoneal injection to rat, Abstract;
Peroxisome proliferator-activated receptors: structures and function: J.D. Tugwood, et al.; Ann. N. Y. Acad. Sci. 804, 252 (1996), Abstract;
The PPARalpha-leukotriene B4 pathway to inflammation control: P.R. Devchand, et al.; Nature 384, 39 (1996), Abstract;
Peroxisome proliferator-activated receptors A link between endocrinology and nutrition?: H. Keller & W. Wahli; Trends Endocrinol. Metab. 4, 291 (1993), Abstract;
Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors: C. Dreyer, et al.; Cell 68, 879 (1992), Abstract;
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators: I. Issemann & S. Green; Nature 347, 645 (1990), Abstract;

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