Replaces Prod. #: ALX-270-198
WY-14643 is a potent and widely used peroxisome proliferator activator receptor (PPAR) activator. It has been shown to be selective for PPARα.
Product Details
| Alternative Name: | Pirinixic acid |
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| Formula: | C14H14ClN3O2S |
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| MW: | 323.8 |
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| CAS: | 50892-23-4 |
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| RTECS: | AG2915000 |
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| Purity: | ≥97% (HPLC) |
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| Identity: | Determined by NMR. |
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| Appearance: | White to off-white solid. |
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| MeltingPoint: | 155-157°C |
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| Solubility: | Soluble in ethyl acetate or dilute base or slightly soluble in alcohol. |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | Ambient |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
Hypoxic postconditioning promotes neurogenesis by modulating the metabolism of neural stem cells after cerebral ischemia: H. Li, et al.; Exp. Neurol.
347, 113871 (2021),
Abstract;
Natural helix 9 mutants of PPARĪ³ differently affect its transcriptional activity: M.F. Brokekema, et al.; Mol. Metab.
20, 115 (2019),
Abstract;
CRY1/2 Selectively Repress PPARd and Limit Exercise Capacity: S.D. Jordan, et al.; Cell Metab.
26, 243 (2017),
Abstract;
Full Text
Characterization of stem cell-derived liver and intestinal organoids as a model system to study nuclear receptor biology: I.T. Bijsmans, et al.; Biochim. Biophys. Acta
1863, 687 (2016),
Abstract;
PPAR alpha Activation Reduces Hepatic CEACAM1 Expression to Regulate Fatty Acid Oxidation during Fasting-refeeding Transition: S.K. Ramakrishnan, et al.; J. Biol. Chem.
291, 8121 (2016),
Application(s): Ingested by mice,
Abstract;
Full Text
Systemic administration of WY-14643, a selective synthetic agonist of peroxisome proliferator activator receptor-alpha, alters spinal neuronal firing in a rodent model of neuropathic pain: B.N. Okine, et al.; Scand. J. Pain.
9, 42 (2015),
Application(s): Intraperitoneal injection to rat,
Abstract;
Peroxisome proliferator-activated receptors: structures and function: J.D. Tugwood, et al.; Ann. N. Y. Acad. Sci.
804, 252 (1996),
Abstract;
The PPARalpha-leukotriene B4 pathway to inflammation control: P.R. Devchand, et al.; Nature
384, 39 (1996),
Abstract;
Peroxisome proliferator-activated receptors A link between endocrinology and nutrition?: H. Keller & W. Wahli; Trends Endocrinol. Metab.
4, 291 (1993),
Abstract;
Control of the peroxisomal beta-oxidation pathway by a novel family of nuclear hormone receptors: C. Dreyer, et al.; Cell
68, 879 (1992),
Abstract;
Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators: I. Issemann & S. Green; Nature
347, 645 (1990),
Abstract;
