Retinoic acid analog which acts as a selective RARα agonist with no affinity for RXRs. Induces differentiation in leukemia cell lines and inhibits angiogenesis in chick embryos.
Product Details
| Formula: | C22H25NO3 |
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| MW: | 351.4 |
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| CAS: | 102121-60-8 |
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| Purity: | ≥98% (TLC) |
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| Appearance: | White to off-white solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) and ethanol (10mg/ml). |
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| Shipping: | Ambient Temperature |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
AM580, a stable benzoic derivative of retinoic acid, has powerful and selective cyto-differentiating effects on acute promyelocytic leukemia cells: M. Gianni, et al.; Blood
87, 1520 (1996),
Abstract;
Myeloid differentiation and retinoblastoma phosphorylation changes in HL-60 cells induced by retinoic acid receptor- and retinoid X receptor-selective retinoic acid analogs: S.C. Brooks, et al.; Blood
87, 227 (1996),
Abstract;
Three novel synthetic retinoids, Re 80, Am 580 and Am 80, all exhibit anti-angiogenic activity in vivo: T. Oikawa, et al.; Eur. J. Pharmacol.
249, 113 (1993),
Abstract;
Selective synthetic ligands for human nuclear retinoic acid receptors: B. Martin, et al.; Skin Pharmacol.
5, 57 (1992),
Abstract;
