An analog of all trans retinoic acid that shows antiproliferative activity on cultured human breast cancer cells. Highly selective activator of retinoid receptors. Induces apoptosis in malignant hemopoietic cell lines.
Product Details
| Alternative Name: | Fenretinide |
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| Formula: | C26H33NO2 |
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| MW: | 391.5 |
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| Source: | Synthetic. |
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| CAS: | 65646-68-6 |
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| Purity: | ≥97% (TLC) |
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| Appearance: | Orange solid. |
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| Solubility: | Soluble in DMSO (25mg/ml) or 100% ethanol (25mg/ml). |
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| Shipping: | Blue Ice |
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| Long Term Storage: | -20°C |
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| Regulatory Status: | RUO - Research Use Only |
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Product Literature References
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Application(s): Cell culture,
Abstract;
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Abstract;
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Differential effects of N-(4-hydroxyphenyl)retinamide and retinoic acid on neuroblastoma cells: apoptosis versus differentiation: M. Ponzoni, et al.; Cancer Res.
55, 853 (1995),
Abstract;
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N-(4-hydroxyphenyl)retinamide induces apoptosis of malignant hemopoietic cell lines including those unresponsive to retinoic acid: D. Delia, et al.; Cancer Res.
53, 6036 (1993),
Abstract;
Effect of retinyl acetate and 4-hydroxyphenylretinamide on initiation of chemically-induced mammary tumors: C. J. Grubbs, et al.; Anticancer Res.
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Abstract;
Effect of 4-hydroxyphenylretinamide and retinoic acid on proliferation and cell cycle of cultured human breast cancer cells: C. Marth, et al.; J. Natl. Cancer Inst.
75, 871 (1985),
Abstract;
